Highly Active, Entirely Biobased Antimicrobial ...
Document type :
Article dans une revue scientifique: Article original
DOI :
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Title :
Highly Active, Entirely Biobased Antimicrobial Pickering Emulsions
Author(s) :
Leclercq, Loïc [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Département de Chimie [Montréal]
Tessier, Jérémie [Auteur]
Département de Chimie [Montréal]
Nardello-Rataj, Véronique [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Schmitzer, Andreea‐Ruxandra [Auteur]
Département de Chimie [Montréal]

Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Département de Chimie [Montréal]
Tessier, Jérémie [Auteur]
Département de Chimie [Montréal]
Nardello-Rataj, Véronique [Auteur]

Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Schmitzer, Andreea‐Ruxandra [Auteur]
Département de Chimie [Montréal]
Journal title :
ChemMedChem
Abbreviated title :
ChemMedChem
Volume number :
16
Pages :
2223-2230
Publisher :
Wiley-VCH Verlag
Publication date :
2021-07-20
ISSN :
1860-7179, 1860-7187
English keyword(s) :
biobased Pickering emulsion
undecylenic acid
cyclodextrin
phytochemical
antimicrobial and anti-biofilm
undecylenic acid
cyclodextrin
phytochemical
antimicrobial and anti-biofilm
HAL domain(s) :
Chimie/Chimie organique
English abstract : [en]
We present the development of surfactant-free, silica-free and fully biobased oil-in-water antimicrobial Pickering emulsions, based on the self-assembly of β-cyclodextrin and phytoantimicrobial oils (terpinen-4-ol or ...
Show more >We present the development of surfactant-free, silica-free and fully biobased oil-in-water antimicrobial Pickering emulsions, based on the self-assembly of β-cyclodextrin and phytoantimicrobial oils (terpinen-4-ol or carvacrol). Undecylenic acid (UA), derived from castor oil, can be used as bio-based drug to treat fungal infection, but is less effective than petroleum-based drugs as azole derivatives. To maximize its antifungal potential, we have incorporated UA in fully biobased Pickering emulsions. These emulsions are effective against fungi, Gram-positive and Gram-negative bacteria. The carvacrol emulsion charged with UA is +390 % and +165 % more potent against methicillin-resistant S. aureus (MRSA), compared to UA and azole-based commercial formulations. Moreover, this emulsion is up to +480 % more efficient that UA ointment against C. albicans. Finally, remarkable eradication of E. coli and MRSA biofilms was obtained with this environmental-friendly emulsion.Show less >
Show more >We present the development of surfactant-free, silica-free and fully biobased oil-in-water antimicrobial Pickering emulsions, based on the self-assembly of β-cyclodextrin and phytoantimicrobial oils (terpinen-4-ol or carvacrol). Undecylenic acid (UA), derived from castor oil, can be used as bio-based drug to treat fungal infection, but is less effective than petroleum-based drugs as azole derivatives. To maximize its antifungal potential, we have incorporated UA in fully biobased Pickering emulsions. These emulsions are effective against fungi, Gram-positive and Gram-negative bacteria. The carvacrol emulsion charged with UA is +390 % and +165 % more potent against methicillin-resistant S. aureus (MRSA), compared to UA and azole-based commercial formulations. Moreover, this emulsion is up to +480 % more efficient that UA ointment against C. albicans. Finally, remarkable eradication of E. coli and MRSA biofilms was obtained with this environmental-friendly emulsion.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Other project(s) or funding source(s) :
Natural Sciences and Engineering Research Council of Canada (NSERC)
Ministère de l′Enseignement Supérieur et de la Recherche
Région Hauts de France
Université de Montréal
Université de Lille
Ministère de l′Enseignement Supérieur et de la Recherche
Région Hauts de France
Université de Montréal
Université de Lille
Administrative institution(s) :
CNRS
Centrale Lille
ENSCL
Univ. Artois
Université de Lille
Centrale Lille
ENSCL
Univ. Artois
Université de Lille
Collections :
Research team(s) :
Colloïdes catalyse oxydation (CÏSCO)
Submission date :
2022-03-24T09:02:55Z
2023-12-15T14:17:40Z
2023-12-15T14:17:40Z
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