Title :

Effect of lactobacillus reuteri on gingival inflammation and composition of the oral microbiota in patients undergoing treatment with fixed orthodontic appliances: study protocol of a randomized control trial

Author(s) :

Agossa, Kevimy [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Dubar, Marie [Auteur]
Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille]
Lemaire, Gregoire [Auteur]
Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille]
Blaizot, Alessandra [Auteur]
CIC CHU ( Lille)/inserm
Catteau, Celine [Auteur]
CIC CHU ( Lille)/inserm
Bocquet, Emmanuelle [Auteur]

Nawrocki, Laurent [Auteur]
CIC CHU ( Lille)/inserm
Boyer, Emile [Auteur]
CHU Pontchaillou [Rennes]
Meuric, Vincent [Auteur]
CHU Pontchaillou [Rennes]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008

Journal title :

Pathogens

Abbreviated title :

Pathogens

Volume number :

11

Pages :

112

Publication date :

2022-01-18

ISSN :

2076-0817

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The effect of probiotics in improving or maintaining oral health in orthodontic patients is understudied. The aim of this study is to evaluate the effect of probiotic administration in addition to tooth brushing on clinical ...
Show more >The effect of probiotics in improving or maintaining oral health in orthodontic patients is understudied. The aim of this study is to evaluate the effect of probiotic administration in addition to tooth brushing on clinical gingival inflammation, plaque formation, subgingival microbiota composition, and salivary biomarkers of inflammation in adolescents with fixed orthodontic appliances. The present study is a 6-month, double-blind, two-arm, placebo-controlled, single-center trial, in which 116 adolescent volunteers aged 12-16 years will be recruited from the patients of the orthodontics clinic of the University Hospital of Lille, France. Subjects who meet the eligibility criteria will be allocated to one of the following groups: (i) control: two placebo lozenges per day for 90 days together with regular oral hygiene, (ii) test: two probiotic lozenges per day for 90 days together with regular oral hygiene. Clinical assessment and biological sample collection will be performed at baseline, 3 and 6 months. In addition, compliance outcomes and adverse events will be monitored.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

U1008

Submission date :

2022-04-13T07:12:01Z
2022-11-08T11:28:15Z