Title :

Clinical translation of advanced colonic drug delivery technologies

Author(s) :

Awad, Atheer [Auteur]
Madla, Christine M. [Auteur]
Mccoubrey, Laura E. [Auteur]
Ferraro, Fabiana [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Gavins, Francesca K. H. [Auteur]
Buanz, Asma [Auteur]
Gaisford, Simon [Auteur]
Orlu, Mine [Auteur]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Basit, Abdul W. [Auteur]

Journal title :

Advanced drug delivery reviews

Abbreviated title :

Adv Drug Deliv Rev

Volume number :

181

Pages :

114076

Publication date :

2021-12-07

ISSN :

1872-8294

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. ...
Show more >Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a range of traditional colonic delivery technologies are available, these systems exhibit inconsistent drug release due to physiological variability between and within individuals, which may be further exacerbated by underlying disease states. In recent years, significant translational and commercial advances have been made with the introduction of new technologies that incorporate independent multi-stimuli release mechanisms (pH and/or microbiota-dependent release). Harnessing these advanced technologies offers new possibilities for drug delivery via the colon, including the delivery of biopharmaceuticals, vaccines, nutrients, and microbiome therapeutics for the treatment of both local and systemic diseases. This review details the latest advances in colonic drug delivery, with an emphasis on emerging therapeutic opportunities and clinical technology translation.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Research team(s) :

U1008

Submission date :

2022-04-13T07:12:05Z