Clinical translation of advanced colonic ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
Permalink :
Title :
Clinical translation of advanced colonic drug delivery technologies
Author(s) :
Awad, Atheer [Auteur]
University College of London [London] [UCL]
Madla, Christine M. [Auteur]
University College of London [London] [UCL]
Mccoubrey, Laura E. [Auteur]
University College of London [London] [UCL]
Ferraro, Fabiana [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Gavins, Francesca K. H. [Auteur]
University College of London [London] [UCL]
Buanz, Asma [Auteur]
University College of London [London] [UCL]
Gaisford, Simon [Auteur]
University College of London [London] [UCL]
Orlu, Mine [Auteur]
University College of London [London] [UCL]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Basit, Abdul W. [Auteur]
University College of London [London] [UCL]
University College of London [London] [UCL]
Madla, Christine M. [Auteur]
University College of London [London] [UCL]
Mccoubrey, Laura E. [Auteur]
University College of London [London] [UCL]
Ferraro, Fabiana [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Gavins, Francesca K. H. [Auteur]
University College of London [London] [UCL]
Buanz, Asma [Auteur]
University College of London [London] [UCL]
Gaisford, Simon [Auteur]
University College of London [London] [UCL]
Orlu, Mine [Auteur]
University College of London [London] [UCL]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Basit, Abdul W. [Auteur]
University College of London [London] [UCL]
Journal title :
Advanced Drug Delivery Reviews
Abbreviated title :
Adv Drug Deliv Rev
Volume number :
181
Pages :
114076
Publication date :
2021-12-07
ISSN :
1872-8294
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. ...
Show more >Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a range of traditional colonic delivery technologies are available, these systems exhibit inconsistent drug release due to physiological variability between and within individuals, which may be further exacerbated by underlying disease states. In recent years, significant translational and commercial advances have been made with the introduction of new technologies that incorporate independent multi-stimuli release mechanisms (pH and/or microbiota-dependent release). Harnessing these advanced technologies offers new possibilities for drug delivery via the colon, including the delivery of biopharmaceuticals, vaccines, nutrients, and microbiome therapeutics for the treatment of both local and systemic diseases. This review details the latest advances in colonic drug delivery, with an emphasis on emerging therapeutic opportunities and clinical technology translation.Show less >
Show more >Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a range of traditional colonic delivery technologies are available, these systems exhibit inconsistent drug release due to physiological variability between and within individuals, which may be further exacerbated by underlying disease states. In recent years, significant translational and commercial advances have been made with the introduction of new technologies that incorporate independent multi-stimuli release mechanisms (pH and/or microbiota-dependent release). Harnessing these advanced technologies offers new possibilities for drug delivery via the colon, including the delivery of biopharmaceuticals, vaccines, nutrients, and microbiome therapeutics for the treatment of both local and systemic diseases. This review details the latest advances in colonic drug delivery, with an emphasis on emerging therapeutic opportunities and clinical technology translation.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Collections :
Research team(s) :
U1008
Submission date :
2022-04-13T07:12:05Z
2024-02-16T13:53:53Z
2024-02-16T13:53:53Z