Title :

Cochlear implantation and other treatments in single-sided deafness and asymmetric hearing loss: results of a national multicenter study including a randomized controlled trial

Author(s) :

Marx, Mathieu [Auteur]
Centre de recherche cerveau et cognition [CERCO UMR5549]
Mosnier, Isabelle [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Venail, Frederic [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Mondain, Michel [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Uziel, Alain [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Bakhos, David [Auteur]
Université de Tours [UT]
Lescanne, Emmanuel [Auteur]
Hôpital Bretonneau
N'guyen, Yann [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
CHU Pitié-Salpêtrière [AP-HP]
Bernardeschi, Daniele [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Sterkers, Olivier [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Deguine, Olivier [Auteur]
Centre de recherche cerveau et cognition [CERCO UMR5549]
Lepage, Benoit [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Godey, Benoit [Auteur]
Université de Rennes - Faculté de Médecine [UR Médecine]
Schmerber, Sebastien [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Bonne, Nicolas-Xavier [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Vincent, Christophe [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Fraysse, Bernard [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]

Journal title :

Audiology and Neurotology

Abbreviated title :

Audiol Neurootol

Volume number :

26

Pages :

1-11

Publication date :

2021-03-31

ISSN :

1421-9700

English keyword(s) :

Bone-anchored hearing system
Asymmetric hearing loss
Cochlear implants
Quality of life
Contralateral routing of the signal hearing Aids

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Cochlear implantation is a recent approach proposed to treat single-sided deafness (SSD) and asymmetric hearing loss (AHL). Several cohort studies showed its effectiveness on tinnitus and variable results on binaural ...
Show more >Cochlear implantation is a recent approach proposed to treat single-sided deafness (SSD) and asymmetric hearing loss (AHL). Several cohort studies showed its effectiveness on tinnitus and variable results on binaural hearing. The main objective of this study is to assess the outcomes of cochlear implantation and other treatment options in SSD/AHL on quality of life. This prospective multicenter study was conducted in 7 tertiary university hospitals and included an observational cohort study of SSD/AHL adult patients treated using contralateral routing of the signal (CROS) hearing aids or bone-anchored hearing systems (BAHSs) or who declined all treatments, and a randomized controlled trial in subjects treated by cochlear implantation, after failure of CROS and BAHS trials. In total, 155 subjects with SSD or AHL, with or without associated tinnitus, were enrolled. After 2 consecutive trials with CROS hearing aids and BAHSs on headband, all subjects chose any of the 4 treatment options (abstention, CROS, BAHS, or cochlear implant [CI]). The subjects who opted for a CI were randomized between 2 arms (CI vs. initial observation). Six months after the treatment choice, quality of life was assessed using both generic (EuroQoL-5D, EQ-5D) and auditory-specific quality-of-life indices (Nijmegen Cochlear implant Questionnaire [NCIQ] and Visual Analogue Scale [VAS] for tinnitus severity). Performances for speech-in-noise recognition and localization were measured as secondary outcomes. CROS was chosen by 75 subjects, while 51 opted for cochlear implantation, 18 for BAHSs, and 11 for abstention. Six months after treatment, both EQ-5D VAS and auditory-specific quality-of-life indices were significantly better in the "CI" arm versus "observation" arm. The mean effect of the CI was particularly significant in subjects with associated severe tinnitus (mean improvement of 20.7 points ± 19.7 on EQ-5D VAS, 20.4 ± 12.4 on NCIQ, and 51.4 ± 35.4 on tinnitus). No significant effect of the CI was found on binaural hearing results. Before/after comparisons showed that the CROS and BAHS also improved significantly NCIQ scores (for CROS: +7.7, 95% confidence interval [95% CI] = [4.5; 10.8]; for the BAHS: +14.3, 95% CI = [7.9; 20.7]). Cochlear implantation leads to significant improvements in quality of life in SSD and AHL patients, particularly in subjects with associated severe tinnitus, who are thereby the best candidates to an extension of CI indications.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Research team(s) :

U1008

Submission date :

2022-04-13T07:12:10Z
2024-02-21T08:22:09Z