Crouzon syndrome: posterior fossa volume studies in vestibular orientation

Pellerin, Philippe; Vinchon, Matthieu; Dhellemmes, Patrick; Guerreschi, Pierre

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1007/s00381-021-05186-9

PMID :

33904938

URL permanente :

http://hdl.handle.net/20.500.12210/73630

Titre :

Crouzon syndrome: posterior fossa volume studies in vestibular orientation

Auteur(s) :

Pellerin, Philippe [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Vinchon, Matthieu [Auteur]

Maladies Rares du Développement : Génétique, Régulation et Protéomique (RADEME) - ULR 7364
Dhellemmes, Patrick [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Guerreschi, Pierre [Auteur]

Advanced Drug Delivery Systems (ADDS) - U1008

Titre de la revue :

Child's Nervous System

Nom court de la revue :

Childs Nerv Syst

Numéro :

Pagination :

3105–3111

Date de publication :

2021-04-27

ISSN :

1433-0350

Mot(s)-clé(s) en anglais :

Imaging post-processing
Pathophysiology
Craniology
Craniofacial dysostosis

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

With the increasing possibilities of surgical treatment addressing the complex spectrum of defects in Crouzon syndrome (CS), it is of utmost importance to obtain accurate assessment of the malformation. Evaluating the ...
Lire la suite >With the increasing possibilities of surgical treatment addressing the complex spectrum of defects in Crouzon syndrome (CS), it is of utmost importance to obtain accurate assessment of the malformation. Evaluating the volume of the posterior fossa is of great importance since many authors, considering that its volume is always decreased, favor posterior fossa enlargement as a first step in the treatment of CS. We studied CT scans of children with CS, which were vestibular-oriented (VO) in order to conform with physiological landmarks, and we measured intracranial volume by manual segmentation; these abnormal CT scans were superposed with VO 3D-CT scanners of age-matched controls. We studied the volume index of the posterior fossa for each CS patient defined as the ratio of its volume in CS patients with the normal for age calculated from normal controls. We studied the imaging of 41 children with CS and 70 control. Among CS patients, the volume of the posterior fossa was increased in 10, compared with control. We found closure of the sphenoidal synchondrosis was correlated with age and with the width of the posterior fossa, but not with its length nor with the posterior fossa volume index. Segmentation on VO-CT scanner and superposition with CT scanners of normal controls is a powerful tool for the study of the impact of CS or other synostoses on volume and shape. We found that CS is more heterogeneous than previously thought, and surgical strategies should be adapted accordingly.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

Équipe(s) de recherche :

U1008

Date de dépôt :

2022-04-13T07:12:11Z
2024-02-15T10:05:29Z

Numéro de version	Lien	Date de modification
2	20.500.12210/73630*	2024-02-15T10:03:05Z
1	20.500.12210/73630.1	2022-04-13T07:12:11Z

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Crouzon syndrome: posterior fossa volume ...

BibTeX

CSV

Excel

RIS