Title :

Description of a Newly Isolated Blautia faecis Strain and Its Benefit in Mouse Models of Post-Influenza Secondary Enteric and Pulmonary Infections

Author(s) :

Verstraeten, Sophie [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
FHU Paris Center for Microbiome Medicine [FHU PaCeMM]
Sencio, Valentin [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut Pasteur de Lille
Raise, Audrey [Auteur]
Procédés Alimentaires et Microbiologiques [Dijon] [PAM]
Huillet, Eugénie [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
FHU Paris Center for Microbiome Medicine [FHU PaCeMM]
Layec, Séverine [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
Deruyter, Lucie [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut Pasteur de Lille
Heumel, Séverine [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut Pasteur de Lille
Auger, Sandrine [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
FHU Paris Center for Microbiome Medicine [FHU PaCeMM]
Robert, Véronique [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
FHU Paris Center for Microbiome Medicine [FHU PaCeMM]
Langella, Philippe [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
FHU Paris Center for Microbiome Medicine [FHU PaCeMM]
Beney, Laurent [Auteur]
Procédés Microbiologiques et Biotechnologiques [PMB]
Trottein, Francois [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut Pasteur de Lille
Thomas, Muriel [Auteur]
MICrobiologie de l'ALImentation au Service de la Santé [MICALIS]
FHU Paris Center for Microbiome Medicine [FHU PaCeMM]

Journal title :

Nutrients

Pages :

1478

Publisher :

MDPI

Publication date :

2022-04-11

ISSN :

2072-6643

English keyword(s) :

extremely oxygen-sensitive probiotics
anti-inflammatory
pulmonary and enteric superinfection
post-influenza
acetate
Blautia faecis

HAL domain(s) :

Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire

English abstract : [en]

The expanding knowledge on the systemic influence of the human microbiome suggests that fecal samples are underexploited sources of new beneficial strains for extra-intestinal health. We have recently shown that acetate, ...
Show more >The expanding knowledge on the systemic influence of the human microbiome suggests that fecal samples are underexploited sources of new beneficial strains for extra-intestinal health. We have recently shown that acetate, a main circulating microbiota-derived molecule, reduces the deleterious effects of pulmonary Streptococcus pneumoniae and enteric Salmonella enterica serovar Typhimurium bacterial post-influenza superinfections. Considering the beneficial and broad effects of acetate, we intended to isolate a commensal strain, producing acetate and potentially exploitable in the context of respiratory infections. We designed successive steps to select intestinal commensals that are extremely oxygen-sensitive, cultivable after a freezing process, without a proinflammatory effect on IL-8 induction, and producing acetate. We have identified the Blautia faecis DSM33383 strain, which decreased the TNFα-induced production of IL-8 by the intestinal epithelial cell line HT-29. The beneficial effect of this bacterial strain was further studied in two preclinical models of post-influenza Streptococcus pneumoniae (S.p) and Salmonella enterica serovar Typhimurium (S.t) superinfection. The intragastrical administration of Blautia faecis DSM33383 led to protection in influenza-infected mice suffering from an S.p. and, to a lesser extent, from an S.t secondary infection. Altogether, this study showed that Blautia faecis DSM33383 could be a promising candidate for preventive management of respiratory infectious diseases.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

Rôle de l'axe poumon/intestin/moelle osseuse et du microbiote au cours de la grippe
Développement et Optimisation d'un Procédé de Production de Bactéries Extrêmement Sensibles à l'Oxygène pour leur Exploitation Industrielle

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL