Title :

Comparative assessment of local tolerance of alcohols commonly used in alcohol-based hand rubs for hand hygiene

Author(s) :

Manche, Monique [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Foligne, Benoit [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Sauty, Mathieu [Auteur]
Institut Pasteur de Lille
Platel, Anne [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Vercauteren, Eric [Auteur]
Laboratoire de toxicologie génétique [Lille]
Rauwel, Gaetan [Auteur]
Catoire, Sophie [Auteur]
Ficheux, Herve [Auteur]
Criquelion, Jacques [Auteur]
Nesslany, Fabrice [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]

Journal title :

Toxicology in Vitro

Pages :

142-153

Publisher :

Elsevier

Publication date :

2017-10-01

ISSN :

0887-2333

Keyword(s) :

Skin irritation
Hand hygiene
In vitro
Alcohol-based hand rubs
Phototoxicity
Reconstructed human epidermis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Hand hygiene plays a key role in nosocomial infection prevention. To achieve users' adherence, products' dermal tolerance is essential. We aimed at making a comparative assessment of skin irritation and phototoxicity of ...
Show more >Hand hygiene plays a key role in nosocomial infection prevention. To achieve users' adherence, products' dermal tolerance is essential. We aimed at making a comparative assessment of skin irritation and phototoxicity of the 3 alcohols commonly used in alcohol-based hand rubs (Ethanol, Propan-2-ol, Propan-1-ol) at 60, 70, 80 or 85% w/w in water or with co-formulates (hydrating, emollient and skin protective agents). In vitro validated OECD methods 439 and 432 were used. For irritation, EpiSkin™ Small Model was the chosen Reconstructed Human Epidermis (RhE). For phototoxicity, co-formulates alone or in mixture with and without alcohol were tested using BALB/c 3T3 cell cultures. Whilst Ethanol and Propan-2-ol could not be differentiated and displayed good skin tolerance profiles, Propan-1-ol based products lead to significant viability impairments of RhE at 60, 70 or 80% and at 60% in the presence of co-formulates. However, these results could not be reproduced in another RhE model. Taking also into account bibliographic data on Propan-1-ol, this suggests that our results are probably related to a lack of specificity of the used RhE. Therefore, it can be relevant in case of significant results to use two different RhE models before performing any classification and/or performing any complementary tests.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL