Title :

Unexpected Association of Desacyl-Ghrelin with Physical Activity and Chronic Food Restriction: A Translational Study on Anorexia Nervosa

Author(s) :

Duriez, Philibert [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Robichon, Lauralee [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Dardennes, Roland [Auteur]
GHU Paris Psychiatrie et Neurosciences
Lavoisy, Guillaume [Auteur]
GHU Paris Psychiatrie et Neurosciences
Grouselle, Dominique [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Epelbaum, Jacques [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Ramoz, Nicolas [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Gorwood, Philip [Auteur]
GHU Paris Psychiatrie et Neurosciences
Tolle, Virginie [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Viltart, Odile [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Journal title :

JOURNAL OF CLINICAL MEDICINE

Abbreviated title :

J Clin Med

Volume number :

9

Publication date :

2020-08-28

ISSN :

2077-0383

English keyword(s) :

acyl-ghrelin
animal models
chronic food restriction
desacyl-ghrelin
physical activity
restrictive anorexia nervosa
weight recovery

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution ...
Show more >Anorexia nervosa (AN) is a severe metabopsychiatric disorder characterised by caloric intake restriction and often excessive physical exercise. Our aim is to assess in female AN patients and in a rodent model, the co-evolution of physical activity and potential dysregulation of acyl-(AG) and desacyl-(DAG) ghrelin plasma concentrations during denutrition and weight recovery. AN inpatients were evaluated at inclusion (T0, = 29), half-(T1) and total (T2) weight recovery, and one month after discharge (T3, = 13). C57/Bl6 mice with access to a running wheel, were fed ad libitum or submitted to short-(15 days) or long-(50 days) term quantitative food restriction, followed by refeeding (20 days). In AN patients, AG and DAG rapidly decreased during weight recovery (T0 to T2), AG increased significantly one-month post discharge (T3), but only DAG plasma concentrations at T3 correlated negatively with BMI and positively with physical activity. In mice, AG and DAG both increased during short- and long-term food restriction. After 20 days of ad libitum feeding, DAG was associated to persistence of exercise alteration. The positive association of DAG with physical activity during caloric restriction and after weight recovery questions its role in the adaptation mechanisms to energy deprivation that need to be considered in recovery process in AN.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Submission date :

2022-05-04T12:33:04Z
2022-05-10T12:41:07Z