Title :

A Metabolic Perspective on Reward Abnormalities in Anorexia Nervosa.

Author(s) :

Duriez, Philibert [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Ramoz, Nicolas [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm - Paris Descartes]
Gorwood, Philip [Auteur]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Viltart, Odile [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 [SCALab]
Tolle, Virginie [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]

Journal title :

Trends in endocrinology and metabolism: TEM

Abbreviated title :

Trends Endocrinol Metab

Volume number :

30

Pages :

915-928

Publication date :

2019-12

ISSN :

1879-3061

English keyword(s) :

Anorexia Nervosa
Genome-Wide Association Study
Humans
anorexia nervosa
human genetics
metabolic factors
reward abnormalities

HAL domain(s) :

Sciences cognitives

English abstract : [en]

Anorexia nervosa (AN) is the psychiatric disorder with the highest mortality rate; however, the mechanisms responsible for its pathogenesis remain largely unknown. Large-scale genome-wide association studies (GWAS) have ...
Show more >Anorexia nervosa (AN) is the psychiatric disorder with the highest mortality rate; however, the mechanisms responsible for its pathogenesis remain largely unknown. Large-scale genome-wide association studies (GWAS) have identified genetic loci associated with metabolic features in AN. Metabolic alterations that occur in AN have been mostly considered as consequences of the chronic undernutrition state but until recently have not been linked to the etiology of the disorder. We review the molecular basis of AN based on human genetics, with an emphasis on the molecular components controlling energy homeostasis, highlight the main metabolic and endocrine alterations occurring in AN, and decipher the possible connection between metabolic factors and abnormalities of reward processes that are central in AN.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Submission date :

2022-05-04T12:38:57Z
2022-05-11T09:51:10Z