Title :

Metabolic and neuroendocrine adaptations to undernutrition in anorexia nervosa: from a clinical to a basic research point of view.

Author(s) :

Viltart, Odile [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Duriez, Philibert [Auteur]
Centre Hospitalier Sainte Anne [Paris]
Tolle, Virginie [Auteur]
Université Paris Descartes - Paris 5 [UPD5]

Journal title :

Hormone Molecular Biology and Clinical Investigation

Abbreviated title :

Horm Mol Biol Clin Investig

Volume number :

36

Publication date :

2018-03-28

ISSN :

1868-1891

English keyword(s) :

Adaptation, Physiological
Animals
Anorexia Nervosa
Ghrelin
Glucocorticoids
Humans
Leptin
Malnutrition
anorexia nervosa
hormones
metabolic
neuroendocrine
psychiatric disorder
undernutrition

HAL domain(s) :

Sciences cognitives

English abstract : [en]

The exact mechanisms linking metabolic and neuroendocrine adaptations to undernutrition and the pathophysiology of anorexia nervosa (AN) are not fully understood. AN is a psychiatric disorder of complex etiology characterized ...
Show more >The exact mechanisms linking metabolic and neuroendocrine adaptations to undernutrition and the pathophysiology of anorexia nervosa (AN) are not fully understood. AN is a psychiatric disorder of complex etiology characterized by extreme starvation while the disease is progressing into a chronic state. Metabolic and endocrine alterations associated to this disorder are part of a powerful response to maintain whole body energy homeostasis. But these modifications may also contribute to associated neuropsychiatric symptoms (reward abnormalities, anxiety, depression) and thus participate to sustain the disease. The current review presents data with both a clinical and basic research point of view on the role of nutritional and energy sensors with neuroendocrine actions in the pathophysiology of the disease, as they modulate metabolic responses, reproductive functions, stress responses as well as physical activity. While clinical data present a full description of changes occurring in AN, animal models that integrate either spontaneous genetic mutations or experimentally-induced food restriction with hyperactivity and/or social stress recapitulate the main metabolic and endocrine alterations of AN and provide mechanistic information between undernutrition state and symptoms of the disease. Further progress on the central and peripheral mechanism involved in the pathophysiology of eating disorders partly relies on the development and/or refinement of existing animal models to include recently identified genetic traits and better mimic the complex and multifactorial dimensions of the disease.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Submission date :

2022-05-04T12:42:01Z
2022-05-11T07:59:07Z