Title :

Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer

Author(s) :

Simar-Mentieres, Sophie [Auteur]
Institut Pasteur de Lille
Laboratoire de toxicologie génétique [Lille]
Nesslany, Fabrice [Auteur]
Institut Pasteur de Lille
Laboratoire de toxicologie génétique [Lille]
Sola, Marie-Laure [Auteur]
European Research Biology Center [ERBC]
Mortier, Sandra [Auteur]
European Research Biology Center [ERBC]
Raimbault, Jean-Michel [Auteur]
European Research Biology Center [ERBC]
Gondelle, F. [Auteur]
Institut National de l'Environnement Industriel et des Risques [INERIS]
Chabot, L. [Auteur]
Institut National de l'Environnement Industriel et des Risques [INERIS]
Pandard, Pascal [Auteur]
Institut National de l'Environnement Industriel et des Risques [INERIS]
Wils, Daniel [Auteur]
Roquette Frères
Chentouf, Aouatif [Auteur]
Roquette Frères

Journal title :

Journal of Toxicology

Abbreviated title :

Journal of Toxicology

Volume number :

2021

Pages :

9970896

Publisher :

Hindawi Limited

Publication date :

2021-07-12

ISSN :

1687-8205

HAL domain(s) :

Sciences du Vivant [q-bio]/Toxicologie

English abstract : [en]

Phthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications. These phthalate esters ...
Show more >Phthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications. These phthalate esters are low-toxicity environmental contaminants. To address these drawbacks, POLYSORB® ID 37, a blend of diesters obtained from esterification of isosorbide with plant-based fatty acids, was developed. The company can now offer PVC manufacturers a new product which competes with phthalates and other such chemicals. The market for plasticizers is very important, and ROQUETTE intends to provide a more sustainable and safer product. Isosorbide diester is bio-based (made from glucose and vegetable fatty acids). This plasticizer is registered in REACH regulation for high volumes (>1000 T/year). Risk assessment was obtained by conducting a wide range of biodegradability and toxicological protocols, using rodent models, according to established guidelines. Overall, all of the toxicological and biodegradability studies demonstrated that POLYSORB® ID 37 is nontoxic to mammalian life and is readily biodegradable.Show less >

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• Autres travaux scientifiques

Submission date :

2022-05-10T09:44:04Z
2022-05-25T12:21:03Z