Role of GD3 Synthase ST8Sia I in Cancers

Kasprowicz, Angélina; Groux, Sophie; Lagadec, Chann; Delannoy, Philippe

Type de document :

Article dans une revue scientifique

DOI :

10.3390/cancers14051299

URL permanente :

http://hdl.handle.net/20.500.12210/74302

Titre :

Role of GD3 Synthase ST8Sia I in Cancers

Auteur(s) :

Kasprowicz, Angélina [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Groux, Sophie [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Lagadec, Chann [Auteur]

Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277
Delannoy, Philippe [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Titre de la revue :

Cancers

Nom court de la revue :

Cancers

Numéro :

Pagination :

1299

Éditeur :

MDPI AG

Date de publication :

2022-03-03

ISSN :

2072-6694

Mot(s)-clé(s) en anglais :

ganglioside
GD3 synthase
epithelial–mesenchymal transition
transcriptional regulation

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

GD3 synthase controls the biosynthesis of complex gangliosides, bearing two or more sialic acid residues. Disialylated gangliosides GD3 and GD2 are tumor-associated carbohydrate antigens (TACA) in neuro–ectoderm-derived ...
Lire la suite >GD3 synthase controls the biosynthesis of complex gangliosides, bearing two or more sialic acid residues. Disialylated gangliosides GD3 and GD2 are tumor-associated carbohydrate antigens (TACA) in neuro–ectoderm-derived cancers, and are directly involved in cell malignant properties, i.e., migration, invasion, stemness, and epithelial–mesenchymal transition. Since GD3 and GD2 levels are directly linked to GD3 synthase expression and activity, targeting GD3 synthase appears to be a promising strategy through which to interfere with ganglioside-associated malignant properties. We review here the current knowledge on GD3 synthase expression and regulation in cancers, and the consequences of complex ganglioside expression on cancer cell signaling and properties, highlighting the relationships between GD3 synthase expression and epithelial–mesenchymal transition and stemness. Different strategies were used to modulate GD3 synthase expression in cancer cells in vitro and in animal models, such as inhibitors or siRNA/lncRNA, which efficiently reduced cancer cell malignant properties and the proportion of GD2 positive cancer stem cells, which are associated with high metastatic properties, resistance to therapy, and cancer relapse. These data show the relevance of targeting GD3 synthase in association with conventional therapies, to decrease the number of cancer stem cells in tumors.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS

Collections :

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Régulation de la glycosylation terminale

Date de dépôt :

2022-05-12T13:53:13Z
2022-05-25T10:09:23Z

Fichiers

P22.07 Kasprowicz et al. Cancers 2022.pdf
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Ce document est diffusé sous licence Attribution 3.0 United States

Numéro de version	Lien	Date de modification
2	20.500.12210/74302*	2022-05-25T10:06:54Z
1	20.500.12210/74302.1	2022-05-12T13:53:13Z

Role of GD3 Synthase ST8Sia I in Cancers

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Role of GD3 Synthase ST8Sia I in Cancers BibTeX CSV Excel RIS

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Role of GD3 Synthase ST8Sia I in Cancers

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CSV

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