Role of GD3 Synthase ST8Sia I in Cancers

Kasprowicz, Angélina; Groux, Sophie; Lagadec, Chann; Delannoy, Philippe

Document type :

Compte-rendu et recension critique d'ouvrage

DOI :

10.3390/cancers14051299

Title :

Role of GD3 Synthase ST8Sia I in Cancers

Author(s) :

Kasprowicz, Angélina [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Groux, Sophie [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Lagadec, Chann [Auteur]

Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Delannoy, Philippe [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]

Journal title :

Cancers

Pages :

1299

Publisher :

MDPI

Publication date :

2022-03-03

ISSN :

2072-6694

English keyword(s) :

ganglioside
GD3 synthase
epithelial–mesenchymal transition
transcriptional regulation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

GD3 synthase controls the biosynthesis of complex gangliosides, bearing two or more sialic acid residues. Disialylated gangliosides GD3 and GD2 are tumor-associated carbohydrate antigens (TACA) in neuro–ectoderm-derived ...
Show more >GD3 synthase controls the biosynthesis of complex gangliosides, bearing two or more sialic acid residues. Disialylated gangliosides GD3 and GD2 are tumor-associated carbohydrate antigens (TACA) in neuro–ectoderm-derived cancers, and are directly involved in cell malignant properties, i.e., migration, invasion, stemness, and epithelial–mesenchymal transition. Since GD3 and GD2 levels are directly linked to GD3 synthase expression and activity, targeting GD3 synthase appears to be a promising strategy through which to interfere with ganglioside-associated malignant properties. We review here the current knowledge on GD3 synthase expression and regulation in cancers, and the consequences of complex ganglioside expression on cancer cell signaling and properties, highlighting the relationships between GD3 synthase expression and epithelial–mesenchymal transition and stemness. Different strategies were used to modulate GD3 synthase expression in cancer cells in vitro and in animal models, such as inhibitors or siRNA/lncRNA, which efficiently reduced cancer cell malignant properties and the proportion of GD2 positive cancer stem cells, which are associated with high metastatic properties, resistance to therapy, and cancer relapse. These data show the relevance of targeting GD3 synthase in association with conventional therapies, to decrease the number of cancer stem cells in tumors.Show less >

Language :

Anglais

Popular science :

Non

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