Title :

Immunoglobulin Gene Mutational Status Assessment by Next Generation Sequencing in Chronic Lymphocytic Leukemia

Author(s) :

Langlois de Septenville, Anne [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Boudjoghra, Myriam [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Bravetti, Clotilde [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Armand, Marine [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Salson, Mikael [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Giraud, Mathieu [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Davi, Frederic [Auteur]
CHU Pitié-Salpêtrière [AP-HP]

Scientific editor(s) :

Anton W. Langerak

Book title :

Immunogenetics

Publisher :

Springer

Publication date :

2022

ISBN :

978-1-0716-2115-8

English keyword(s) :

Chronic lymphocytic leukemia
Immunoglobulin genes
Next generation sequencing
Somatic hypermutation analysis
Mutational status

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Hématologie
Sciences du Vivant [q-bio]/Immunologie/Immunité adaptative
Informatique [cs]/Bio-informatique [q-bio.QM]

English abstract : [en]

B cell receptor (BcR) immunoglobulins (IG) display a tremendous diversity due to complex DNA rearrangements, the V(D)J recombination, further enhanced by the somatic hypermutation process. In chronic lymphocytic leukemia ...
Show more >B cell receptor (BcR) immunoglobulins (IG) display a tremendous diversity due to complex DNA rearrangements, the V(D)J recombination, further enhanced by the somatic hypermutation process. In chronic lymphocytic leukemia (CLL), the mutational load of the clonal BcR IG expressed by the leukemic cells constitutes an important prognostic and predictive biomarker. Here, we provide a reliable methodology capable of determining the mutational status of IG genes in CLL using high-throughput sequencing, starting from leukemic cell DNA or RNA.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Centre de Recherche en Informatique, Signal et Automatique de Lille (CRIStAL) - UMR 9189

Source :

Harvested from HAL