Glioblastoma quo vadis: will migration and invasiveness reemerge as therapeutic targets?

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1016/j.ctrv.2018.06.017

PMID :

Permalink :

http://hdl.handle.net/20.500.12210/74967

Title :

Glioblastoma quo vadis: will migration and invasiveness reemerge as therapeutic targets?

Author(s) :

Lefranc, Florence [Auteur]
Le Rhun, Emilie [Auteur]
Kiss, Robert [Auteur]
Weller, Michael [Auteur]

Journal title :

Cancer Treatment Reviews

Abbreviated title :

Cancer Treat. Rev.

Volume number :

68

Pages :

145-154

Publication date :

2018-07-01

ISSN :

1532-1967

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

PURPOSE: The purpose of the current review is to highlight, on one hand, the fact that the migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy, and on the other one, the new treatment ...
Show more >PURPOSE: The purpose of the current review is to highlight, on one hand, the fact that the migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy, and on the other one, the new treatment strategies to overcome this obstacle. METHODS: This review surveys several membrane and extracellular molecules involved in glioma cell migration, invasiveness and resistance to apoptosis. RESULTS: This review focuses on signaling pathways implicated in the positive regulation of glioblastoma cell migration, including glutamate and ion channel networks, microtubes and membrane-derived extracellular vesicles (EV) containing microRNAs. Glioma cells release glutamate to the extracellular matrix, inducing neuronal cell death, which may facilitate glioma growth and invasion. Glioma cell migration and invasion are further facilitated through ion channels and transporters that modify cellular volume. Microtubes and EV promote connections and communication among glioma cells and with the microenvironment and are associated with progression and resistance to therapy. Potential therapies linked to these pathways for glioblastoma are being developed. CONCLUSION: Our view is evolving from an intracellular view of the complex intracellular signaling pathways to one of orchestral machinery, including connections between heterogeneous tumoral and nontumoral cells and with the microenvironment through channels, microtubes, and extracellular miRNA, generating different signals at different times. All of these elements give rise to a new perspective for the treatment of glioblastoma.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:57:35Z