Glioblastoma quo vadis: will migration and invasiveness reemerge as therapeutic targets?

Type de document :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1016/j.ctrv.2018.06.017

PMID :

URL permanente :

http://hdl.handle.net/20.500.12210/74967

Titre :

Glioblastoma quo vadis: will migration and invasiveness reemerge as therapeutic targets?

Auteur(s) :

Lefranc, Florence [Auteur]
Le Rhun, Emilie [Auteur]

Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Kiss, Robert [Auteur]
Weller, Michael [Auteur]

Titre de la revue :

Cancer Treatment Reviews

Nom court de la revue :

Cancer Treat. Rev.

Numéro :

68

Pagination :

145-154

Date de publication :

2018-07-01

ISSN :

1532-1967

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

PURPOSE: The purpose of the current review is to highlight, on one hand, the fact that the migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy, and on the other one, the new treatment ...
Lire la suite >PURPOSE: The purpose of the current review is to highlight, on one hand, the fact that the migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy, and on the other one, the new treatment strategies to overcome this obstacle. METHODS: This review surveys several membrane and extracellular molecules involved in glioma cell migration, invasiveness and resistance to apoptosis. RESULTS: This review focuses on signaling pathways implicated in the positive regulation of glioblastoma cell migration, including glutamate and ion channel networks, microtubes and membrane-derived extracellular vesicles (EV) containing microRNAs. Glioma cells release glutamate to the extracellular matrix, inducing neuronal cell death, which may facilitate glioma growth and invasion. Glioma cell migration and invasion are further facilitated through ion channels and transporters that modify cellular volume. Microtubes and EV promote connections and communication among glioma cells and with the microenvironment and are associated with progression and resistance to therapy. Potential therapies linked to these pathways for glioblastoma are being developed. CONCLUSION: Our view is evolving from an intracellular view of the complex intracellular signaling pathways to one of orchestral machinery, including connections between heterogeneous tumoral and nontumoral cells and with the microenvironment through channels, microtubes, and extracellular miRNA, generating different signals at different times. All of these elements give rise to a new perspective for the treatment of glioblastoma.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

INSERM
Université de Lille

Collections :

Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Date de dépôt :

2022-06-15T13:57:35Z
2023-04-21T10:04:31Z

Historique des modifications