Title :

Interlamellar matrix governs human annulus fibrosus multiaxial behavior

Author(s) :

Kandil, Karim [Auteur]
Zairi, Fahmi [Auteur]
Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515
Messager, Tanguy [Auteur]
Unité de Mécanique de Lille (UML) - ULR 7512
Zairi, Fahed [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Journal title :

Scientific Reports

Abbreviated title :

Sci Rep

Volume number :

10

Pages :

19292

Publication date :

2020-11-09

ISSN :

2045-2322

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Establishing accurate structure-property relationships for intervertebral disc annulus fibrosus tissue is a fundamental task for a reliable computer simulation of the human spine but needs excessive theoretical-numerical ...
Show more >Establishing accurate structure-property relationships for intervertebral disc annulus fibrosus tissue is a fundamental task for a reliable computer simulation of the human spine but needs excessive theoretical-numerical-experimental works. The difficulty emanates from multiaxiality and anisotropy of the tissue response along with regional dependency of a complex hierarchic structure interacting with the surrounding environment. We present a new and simple hybrid microstructure-based experimental/modeling strategy allowing adaptation of animal disc model to human one. The trans-species strategy requires solely the basic knowledge of the uniaxial circumferential response of two different animal disc regions to predict the multiaxial response of any human disc region. This work demonstrates for the first time the determining role of the interlamellar matrix connecting the fibers-reinforced lamellae in the disc multiaxial response. Our approach shows encouraging multiaxial predictive capabilities making it a promising tool for human spine long-term prediction.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CNRS
Centrale Lille
IMT Lille Douai
INSERM
Institut Catholique Lille
Univ. Artois
Université de Lille

Collections :

• Laboratoire Génie Civil et géo-Environnement (LGCgE) - ULR 4515
• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
• Unité de Mécanique de Lille (UML) - ULR 7512

Submission date :

2022-06-15T13:57:59Z