Shedding light on the ghost proteome

Cardon, Tristan; Fournier, Isabelle; Salzet, Michel

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1016/j.tibs.2020.10.003

PMID :

33246829

Permalink :

http://hdl.handle.net/20.500.12210/75027

Title :

Shedding light on the ghost proteome

Author(s) :

Cardon, Tristan [Auteur]

Fournier, Isabelle [Auteur]

Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Salzet, Michel [Auteur]

Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Journal title :

Trends in Biochemical Sciences

Abbreviated title :

Trends Biochem Sci

Publication date :

2020-11-24

ISSN :

0968-0004

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Conventionally, eukaryotic mRNAs were thought to be monocistronic, leading to the translation of a single protein. However, large-scale proteomics has led to the identification of proteins translated from alternative open ...
Show more >Conventionally, eukaryotic mRNAs were thought to be monocistronic, leading to the translation of a single protein. However, large-scale proteomics has led to the identification of proteins translated from alternative open reading frames (AltORFs) in mRNAs. AltORFs are found in addition to predicted reference ORFs and noncoding RNA. Alternative proteins are not represented in the conventional protein databases, and this 'Ghost proteome' was not considered until recently. Some of these proteins are functional, and there is growing evidence that they are involved in central functions in physiological and physiopathological contexts. Here, we review how this Ghost proteome fills the gap in our understanding of signaling pathways, establishes new markers of pathologies, and highlights therapeutic targets.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:58:03Z

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