Title :

Cerebrospinal fluid cell-free tumour dna as a liquid biopsy for primary brain tumours and central nervous system metastases

Author(s) :

Seoane, Joan [Auteur]
De Mattos-Arruda, L. [Auteur]
Le Rhun, Emilie [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Bardelli, A. [Auteur]
Weller, M. [Auteur]

Journal title :

Annals of oncology . official journal of the European Society for Medical Oncology

Abbreviated title :

Ann. Oncol.

Publication date :

2018-12-21

ISSN :

1569-8041

Keyword(s) :

cerebrospinal fluid
brain cancer
liquid biopsy
brain metastasis
glioblastoma
circulating cell-free tumour DNA

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Challenges in obtaining tissue specimens from patients with brain tumours limit the diagnosis and molecular characterisation and impair the development of better therapeutic approaches. The analysis of cell-free tumour DNA ...
Show more >Challenges in obtaining tissue specimens from patients with brain tumours limit the diagnosis and molecular characterisation and impair the development of better therapeutic approaches. The analysis of cell-free tumour DNA in plasma (considered a liquid biopsy) has facilitated the characterisation of extra-cranial tumours. However, cell-free tumour DNA in plasma is limited in quantity and may not reliably capture the landscape of genomic alterations of brain tumours. Here, we review recent work assessing the relevance of cell-free tumour DNA from cerebrospinal fluid in the characterisation of brain cancer. We focus on the advances in the use of the cerebrospinal fluid as a source of cell-free tumour DNA to facilitate diagnosis, reveal actionable genomic alterations, monitor responses to therapy, and capture tumour heterogeneity in patients with primary brain tumours and brain and leptomeningeal metastases. Profiling cerebrospinal fluid cell-free tumour DNA provides the opportunity to precisely acquire and monitor genomic information in real time and guide precision therapies.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:58:52Z
2023-04-21T10:06:18Z