Title :

Liquid biopsy in central nervous system metastases: a rano review and proposals for clinical applications

Author(s) :

Boire, Adrienne [Auteur]
Brandsma, Dieta [Auteur]
Brastianos, Priscilla K. [Auteur]
Le Rhun, Emilie [Auteur]
Ahluwalia, Manmeet S. [Auteur]
Junk, Larry [Auteur]
Glantz, Michael [Auteur]
Groves, Morris D. [Auteur]
Lee, Eudocia Q. [Auteur]
Lin, Nancy U. [Auteur]
Raizer, Jeffrey J. [Auteur]
Ruda, Roberta [Auteur]
Weller, Michael [Auteur]
Van Den Bent, Martin J. [Auteur]
Vogelbaum, Michael A. [Auteur]
Chang, Susan M. [Auteur]
Wen, Patrick Y. [Auteur]
Soffietti, Riccardo [Auteur]

Journal title :

Neuro-Oncology

Abbreviated title :

Neuro-oncology

Publication date :

2019-01-22

ISSN :

1523-5866

Keyword(s) :

circulating tumor cells
liquid biopsy
clinical implications
CNS metastases
ctDNA

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary ...
Show more >Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein we critically review available literature on spinal fluid and plasma circulating tumor cells (CTCs) and cell-free tumor (ctDNA) for diagnosis and monitoring of leptomeningeal and parenchymal brain metastases. We discuss technical issues and propose several potential applications of liquid biopsies in different clinical settings (ie, for initial diagnosis, for assessment during treatment, and for guidance of treatment decisions). Last, ongoing clinical studies on CNS metastases that include liquid biopsies are summarized, and recommendations for future clinical studies are provided.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:59:00Z