Title :

Imaging challenges of immunotherapy and targeted therapy in patients with brain metastases: response, progression, and pseudoprogression

Author(s) :

Galldiks, Norbert [Auteur]
Kocher, Martin [Auteur]
Ceccon, Garry [Auteur]
Werner, Jan-Michael [Auteur]
Brunn, Anna [Auteur]
Deckert, Martina [Auteur]
Pope, Whitney B. [Auteur]
Soffietti, Riccardo [Auteur]
Le Rhun, Emilie [Auteur]
Weller, Michael [Auteur]
Tonn, Jorg C. [Auteur]
Fink, Gereon R. [Auteur]
Langen, Karl-Josef [Auteur]

Journal title :

Neuro-Oncology

Abbreviated title :

Neuro-oncology

Publication date :

2019-08-22

ISSN :

1523-5866

Keyword(s) :

radiomics
melanoma
lung cancer
immune checkpoint inhibitors
FET PET
brain metastasis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy (TT) has dramatically improved the prognosis of various cancer types. However, following ICI therapy or TT-either alone (especially ...
Show more >The advent of immunotherapy using immune checkpoint inhibitors (ICIs) and targeted therapy (TT) has dramatically improved the prognosis of various cancer types. However, following ICI therapy or TT-either alone (especially ICI) or in combination with radiotherapy-imaging findings on anatomical contrast-enhanced MRI can be unpredictable and highly variable, and are often difficult to interpret regarding treatment response and outcome. This review aims at summarizing the imaging challenges related to TT and ICI monotherapy as well as combined with radiotherapy in patients with brain metastases, and to give an overview on advanced imaging techniques which potentially overcome some of these imaging challenges. Currently, major evidence suggests that imaging parameters especially derived from amino acid PET, perfusion-/diffusion-weighted MRI, or MR spectroscopy may provide valuable additional information for the differentiation of treatment-induced changes from brain metastases recurrence and the evaluation of treatment response.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:59:26Z