Overview of � druggable � alterations by ...
Type de document :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
URL permanente :
Titre :
Overview of � druggable � alterations by histological subtypes of sarcomas and connective tissue intermediate malignancies
Auteur(s) :
Penel, Nicolas [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Lebellec, Loic [Auteur]
Blay, Jean-Yves [Auteur]
Robin, Yves-Marie [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Lebellec, Loic [Auteur]
Blay, Jean-Yves [Auteur]
Robin, Yves-Marie [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Titre de la revue :
Critical Reviews in Oncology/Hematology
Nom court de la revue :
Crit. Rev. Oncol. Hematol.
Numéro :
150
Pagination :
102960
Date de publication :
2020-04-14
ISSN :
1879-0461
Mot(s)-clé(s) :
Druggable alterations
Personalized treatment
Sarcomas
Molecular targeted therapies
Personalized treatment
Sarcomas
Molecular targeted therapies
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
We summarize herein the literature data about molecular targeted therapies in sarcomas and conjunctive tissue intermediate malignancies. For each clinical setting, the level of evidence, the mechanism of action and the ...
Lire la suite >We summarize herein the literature data about molecular targeted therapies in sarcomas and conjunctive tissue intermediate malignancies. For each clinical setting, the level of evidence, the mechanism of action and the target are described. The two major axes include (i) identification of subgroups of tumors with druggable alteration irrespective of the histological diagnosis (e.g. NTRK), and (ii) druggable target of pathway related to the physiopathology of the tumor: denosumab and bone giant cell tumor, imatinib and soft tissue giant cell tumor, mTOR inhibitor and PECOMA.Lire moins >
Lire la suite >We summarize herein the literature data about molecular targeted therapies in sarcomas and conjunctive tissue intermediate malignancies. For each clinical setting, the level of evidence, the mechanism of action and the target are described. The two major axes include (i) identification of subgroups of tumors with druggable alteration irrespective of the histological diagnosis (e.g. NTRK), and (ii) druggable target of pathway related to the physiopathology of the tumor: denosumab and bone giant cell tumor, imatinib and soft tissue giant cell tumor, mTOR inhibitor and PECOMA.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
INSERM
Université de Lille
INSERM
Université de Lille
Collections :
Date de dépôt :
2022-06-15T13:59:31Z