Title :

Acute Effects of Cocoa Flavanols on Blood Pressure and Peripheral Vascular Reactivity in Type 2 Diabetes Mellitus and Essential Hypertension

Author(s) :

Tanghe, Anouk [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Heyman, Elsa [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Lespagnol, Elodie [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Stautemas, Jan [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Celie, Bert [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Op ‘t Roodt, Jos [Auteur]
Maastricht University [Maastricht]
Rietzschel, Ernst [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Dias Soares, Danusa [Auteur]

Hermans, Nina [Auteur]
University of Antwerp [UA]
Tuenter, Emmy [Auteur]
Universiteit Antwerpen = University of Antwerpen [Antwerpen]
Shadid, Samyah [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Calders, Patrick [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]

Journal title :

Nutrients

Abbreviated title :

Nutrients

Volume number :

14

Pages :

2692

Publisher :

MDPI AG

Publication date :

2022-06-28

ISSN :

2072-6643

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: Type 2 diabetes mellitus (T2DM) is associated with a high risk of vascular complications. Interestingly, cocoa flavanols (CF) can exert beneficial vascular effects in non-diabetic subjects. However, these effects ...
Show more >Background: Type 2 diabetes mellitus (T2DM) is associated with a high risk of vascular complications. Interestingly, cocoa flavanols (CF) can exert beneficial vascular effects in non-diabetic subjects. However, these effects have only been scarcely studied in T2DM. Therefore, we performed a study to assess the effects on vascular reactivity of a single dose of CF (790 mg) in T2DM and whether certain antihypertensive drugs may modulate these effects. Methods: 24 non-diabetic and 11 T2DM subjects were studied in a cross-over design. Fasting blood samples, blood pressure (BP), and arterial vasoreactivity (flow-mediated dilation) were assessed before and 70 min after capsule ingestion. Muscle microvascular reactivity was only assessed after capsule ingestion. Age, waist-to-hip ratio, BP at baseline, and the use of antihypertensive drugs were regarded as covariates in a mixed models analysis. Results: CF ingestion did not affect any parameter. However, independent of the type of capsules ingested, a decrease in diastolic BP by 3 mmHg (95% CI: −4.0; −2.0) and an increase in the change in brachial artery diameter (pre vs. post occlusion) by 0.06 mm (95% CI: 0.01; 0.12) were detected in the non-diabetic group, while they remained unchanged in the T2DM group. Conclusion: No beneficial effects of CF were detected on vascular reactivity parameters in T2DM and non-diabetic participants.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Administrative institution(s) :

Université de Lille
Univ. Artois
Univ. Littoral Côte d’Opale

Collections :

• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Research team(s) :

Activité Physique, Muscle, Santé (APMS)

Submission date :

2022-07-09T16:57:17Z
2022-07-13T06:40:13Z