Title :

Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach

Author(s) :

Carton, Louise [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Niot, Candice [Auteur]
Kyheng, MaÉva [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Petrault, Maud [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
LALOUX, Charlotte [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Potey, Camille [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Lenski, Marie [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Bordet, Regis [Auteur]
Deguil, Julie [Auteur]

Journal title :

Translational Psychiatry

Abbreviated title :

Transl Psychiatry

Volume number :

11

Publisher :

Springer Science and Business Media LLC

Publication date :

2021-12-03

ISSN :

2158-3188

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Several observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial. Our study was designed to assess (i) whether the long-term use of benzodiazepines, at ...
Show more >Several observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial. Our study was designed to assess (i) whether the long-term use of benzodiazepines, at two different doses, has an irreversible effect on cognition, (ii) and whether there is an age-dependent effect. One hundred and five C57Bl/6 male mice were randomly assigned to the 15 mg/kg/day, the 30 mg/kg/day diazepam-supplemented pellets, or the control group. Each group comprised mice aged 6 or 12 months at the beginning of the experiments and treated for 16 weeks. Two sessions of behavioral assessment were conducted: after 8 weeks of treatment and after treatment completion following a 1-week wash-out period. The mid-treatment test battery included the elevated plus maze test, the Y maze spontaneous alternation test, and the open field test. The post-treatment battery was upgraded with three additional tests: the novel object recognition task, the Barnes maze test, and the touchscreen-based paired-associated learning task. At mid-treatment, working memory was impaired in the 15 mg/kg diazepam group compared to the control group (p = 0.005). No age effect was evidenced. The post-treatment assessment of cognitive functions (working memory, visual recognition memory, spatial reference learning and memory, and visuospatial memory) did not significantly differ between groups. Despite a cognitive impact during treatment, the lack of cognitive impairment after long-term treatment discontinuation suggests that benzodiazepines alone do not cause irreversible deleterious effects on cognitive functions and supports the interest of discontinuation in chronically treated patients.Show less >

Language :

Anglais

Audience :

Non spécifiée

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Lille Neurosciences & Cognition (LilNCog) - U 1172
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2022-07-21T06:58:24Z
2022-08-24T07:48:43Z
2022-08-24T10:39:40Z