Lack of direct involvement of a diazepam ...
Type de document :
Article dans une revue scientifique
URL permanente :
Titre :
Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach
Auteur(s) :
Carton, Louise [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Niot, Candice [Auteur]
Kyheng, MaÉva [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Petrault, Maud [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
LALOUX, Charlotte [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Potey, Camille [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Lenski, Marie [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Bordet, Regis [Auteur]
Deguil, Julie [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Niot, Candice [Auteur]
Kyheng, MaÉva [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Petrault, Maud [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
LALOUX, Charlotte [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Potey, Camille [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Lenski, Marie [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Bordet, Regis [Auteur]
Deguil, Julie [Auteur]
Titre de la revue :
Translational Psychiatry
Nom court de la revue :
Transl Psychiatry
Numéro :
11
Éditeur :
Springer Science and Business Media LLC
Date de publication :
2021-12-03
ISSN :
2158-3188
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Several observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial. Our study was designed to assess (i) whether the long-term use of benzodiazepines, at ...
Lire la suite >Several observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial. Our study was designed to assess (i) whether the long-term use of benzodiazepines, at two different doses, has an irreversible effect on cognition, (ii) and whether there is an age-dependent effect. One hundred and five C57Bl/6 male mice were randomly assigned to the 15 mg/kg/day, the 30 mg/kg/day diazepam-supplemented pellets, or the control group. Each group comprised mice aged 6 or 12 months at the beginning of the experiments and treated for 16 weeks. Two sessions of behavioral assessment were conducted: after 8 weeks of treatment and after treatment completion following a 1-week wash-out period. The mid-treatment test battery included the elevated plus maze test, the Y maze spontaneous alternation test, and the open field test. The post-treatment battery was upgraded with three additional tests: the novel object recognition task, the Barnes maze test, and the touchscreen-based paired-associated learning task. At mid-treatment, working memory was impaired in the 15 mg/kg diazepam group compared to the control group (p = 0.005). No age effect was evidenced. The post-treatment assessment of cognitive functions (working memory, visual recognition memory, spatial reference learning and memory, and visuospatial memory) did not significantly differ between groups. Despite a cognitive impact during treatment, the lack of cognitive impairment after long-term treatment discontinuation suggests that benzodiazepines alone do not cause irreversible deleterious effects on cognitive functions and supports the interest of discontinuation in chronically treated patients.Lire moins >
Lire la suite >Several observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial. Our study was designed to assess (i) whether the long-term use of benzodiazepines, at two different doses, has an irreversible effect on cognition, (ii) and whether there is an age-dependent effect. One hundred and five C57Bl/6 male mice were randomly assigned to the 15 mg/kg/day, the 30 mg/kg/day diazepam-supplemented pellets, or the control group. Each group comprised mice aged 6 or 12 months at the beginning of the experiments and treated for 16 weeks. Two sessions of behavioral assessment were conducted: after 8 weeks of treatment and after treatment completion following a 1-week wash-out period. The mid-treatment test battery included the elevated plus maze test, the Y maze spontaneous alternation test, and the open field test. The post-treatment battery was upgraded with three additional tests: the novel object recognition task, the Barnes maze test, and the touchscreen-based paired-associated learning task. At mid-treatment, working memory was impaired in the 15 mg/kg diazepam group compared to the control group (p = 0.005). No age effect was evidenced. The post-treatment assessment of cognitive functions (working memory, visual recognition memory, spatial reference learning and memory, and visuospatial memory) did not significantly differ between groups. Despite a cognitive impact during treatment, the lack of cognitive impairment after long-term treatment discontinuation suggests that benzodiazepines alone do not cause irreversible deleterious effects on cognitive functions and supports the interest of discontinuation in chronically treated patients.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Équipe(s) de recherche :
Troubles cognitifs dégénératifs et vasculaires
Date de dépôt :
2022-07-21T06:58:24Z
2022-08-24T07:48:43Z
2022-08-24T10:39:40Z
2022-08-24T07:48:43Z
2022-08-24T10:39:40Z
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