Immune–metabolic interactions in homeostasis and the progression to NASH

Hoogerland, Joanne; Staels, Bart; Dombrowicz, David

Document type :

Article dans une revue scientifique

DOI :

10.1016/j.tem.2022.07.001

PMID :

35961913

Title :

Immune–metabolic interactions in homeostasis and the progression to NASH

Author(s) :

Hoogerland, Joanne [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires [RNMCD - U1011]
Staels, Bart [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires [RNMCD - U1011]
Dombrowicz, David [Auteur correspondant]

Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires [RNMCD - U1011]

Journal title :

Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism

Pages :

S1043-2760(22)00132-1.

Publisher :

Elsevier

Publication date :

2022-08

ISSN :

1043-2760

English keyword(s) :

NAFLD
NASH
immunology
liver
metabolism

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) and predisposes to fibrosis ...
Show more >The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH) and predisposes to fibrosis and hepatocellular carcinoma (HCC). The importance of the immune system in hepatic physiology and in the progression of NAFLD is increasingly recognized. At homeostasis, the liver participates in immune defense against pathogens and in tolerance of gut-derived microbial compounds. Hepatic immune cells also respond to metabolic stimuli and have a role in NAFLD progression to NASH. In this review, we discuss how metabolic perturbations affect immune cell phenotype and function in NAFL and NASH, and then focus on the role of immune cells in liver homeostasis and in the development of NASH.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

EGID Diabetes Pole
PreciNASH

Collections :

Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (EGID) - U1011

Source :

Harvested from HAL

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