Title :

The melting of glucose

Author(s) :

willart, Jean-François [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Ouerghemmi, S. [Auteur]
Descamps, N. [Auteur]
Roquette Frères
Heijboer, P. [Auteur]
Roquette Frères
Paccou, Laurent [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Danede, Florence [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Descamps, Marc [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]

Journal title :

International Journal of Pharmaceutics

Abbreviated title :

International Journal of Pharmaceutics

Volume number :

626

Pages :

122185

Publisher :

Elsevier BV

Publication date :

2022-10

ISSN :

0378-5173

English keyword(s) :

Glucose
Physical stability
Anomers
Mutarotation
Liquefaction
Melting
Eutectic

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

English abstract : [en]

Several sugars are known to undergo a spontaneous liquefaction below their reputed melting point (Tm), but the origin of this apparent melting is not yet clearly understood. In this paper we address this puzzling behavior ...
Show more >Several sugars are known to undergo a spontaneous liquefaction below their reputed melting point (Tm), but the origin of this apparent melting is not yet clearly understood. In this paper we address this puzzling behavior in the particular case of the crystalline forms of glucose: Gα and Gβ, involving respectively the glucose-α and glucose-β anomers. We show in particular that the spontaneous melting below their reputed melting point Tm (∼151 °C for Gα and ∼156 °C for Gβ) corresponds to a horizontal displacement of the system in the eutectic phase diagram of the anomeric mixture glucose-α / glucose-β. This displacement is associated with mutarotation in the liquid which, in turn, induces additional liquefaction of the remaining crystal. This feedback loop creates a vicious circle which stops when the mixture reaches the liquidus branch, i.e. when the liquefaction is total. It is also shown that this behavior becomes more complex on approaching the eutectic temperature Te (120 °C). Just above Te, the liquefaction process is followed by a recrystallization leading to the crystalline form Gβ. On the other hand, just below Te, the spontaneous liquefaction process stops as no melting is expected whatever the anomeric composition.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2022-10-10T15:07:32Z
2022-10-12T06:59:55Z