Titre :

The melting of glucose

Auteur(s) :

willart, Jean-François [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Ouerghemmi, S. [Auteur]
Descamps, N. [Auteur]
Roquette Frères
Heijboer, P. [Auteur]
Roquette Frères
Paccou, Laurent [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Danede, Florence [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Descamps, Marc [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]

Titre de la revue :

International Journal of Pharmaceutics

Nom court de la revue :

International Journal of Pharmaceutics

Numéro :

626

Pagination :

122185

Éditeur :

Elsevier BV

Date de publication :

2022-10

ISSN :

0378-5173

Mot(s)-clé(s) en anglais :

Glucose
Physical stability
Anomers
Mutarotation
Liquefaction
Melting
Eutectic

Discipline(s) HAL :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

Résumé en anglais : [en]

Several sugars are known to undergo a spontaneous liquefaction below their reputed melting point (Tm), but the origin of this apparent melting is not yet clearly understood. In this paper we address this puzzling behavior ...
Lire la suite >Several sugars are known to undergo a spontaneous liquefaction below their reputed melting point (Tm), but the origin of this apparent melting is not yet clearly understood. In this paper we address this puzzling behavior in the particular case of the crystalline forms of glucose: Gα and Gβ, involving respectively the glucose-α and glucose-β anomers. We show in particular that the spontaneous melting below their reputed melting point Tm (∼151 °C for Gα and ∼156 °C for Gβ) corresponds to a horizontal displacement of the system in the eutectic phase diagram of the anomeric mixture glucose-α / glucose-β. This displacement is associated with mutarotation in the liquid which, in turn, induces additional liquefaction of the remaining crystal. This feedback loop creates a vicious circle which stops when the mixture reaches the liquidus branch, i.e. when the liquefaction is total. It is also shown that this behavior becomes more complex on approaching the eutectic temperature Te (120 °C). Just above Te, the liquefaction process is followed by a recrystallization leading to the crystalline form Gβ. On the other hand, just below Te, the spontaneous liquefaction process stops as no melting is expected whatever the anomeric composition.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Matériaux Moléculaires et Thérapeutiques

Date de dépôt :

2022-10-10T15:07:32Z
2022-10-12T06:59:55Z