Titre :

Hot melt extruded PLGA implants loaded with ibuprofen: How heat exposure alters the physical drug state

Auteur(s) :

Bassand, C. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Benabed, L. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Verin, J. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Danede, Florence [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Lefol, L.A. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
willart, Jean-François [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Siepmann, F. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Siepmann, J. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Benabed, L. [Auteur]

Titre de la revue :

Journal of Drug Delivery Science and Technology

Nom court de la revue :

Journal of Drug Delivery Science and Technology

Numéro :

73

Pagination :

103432

Éditeur :

Elsevier BV

Date de publication :

2022-07

ISSN :

1773-2247

Mot(s)-clé(s) en anglais :

PLGA
Implant
Drug release mechanism
Swelling
Monolithic solution
Solid dispersion

Discipline(s) HAL :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

Résumé en anglais : [en]

Hot melt extrusion offers an interesting potential for the manufacturing of poly(lactic-co-glycolic acid) (PLGA)-based implants. However, the heat treatment might substantially alter the polymer, drug and degree of ...
Lire la suite >Hot melt extrusion offers an interesting potential for the manufacturing of poly(lactic-co-glycolic acid) (PLGA)-based implants. However, the heat treatment might substantially alter the polymer, drug and degree of drug-polymer mixing. The aim of this study was to better understand the impact of varying the exposure time to 105 °C in the case of ibuprofen-loaded PLGA implants. In vitro drug release was measured in phosphate buffer pH 7.4. Optical and scanning electron microscopy, DSC, GPC, X-ray diffraction as well as gravimetric analysis were used to monitor dynamic changes of the implants’ morphology, dry & wet mass and average polymer molecular weight. Interestingly, increasing the exposure time from 3 to 15 min led to a decrease in the amount of crystalline drug present in the system, resulting in a slight decrease in the initial burst release. The average PLGA molecular weight also slightly decreased during the heat treatment. In contrast, the relatively rapid penetration of water into the implant and subsequent polymer degradation throughout the device did not seem to be affected to a noteworthy extent. Also the onset of substantial implant swelling after about 1 week and the subsequent beginning of the final rapid drug release phase (accounting for about 80% of the total drug dose) were not significantly altered. Thus, in this study, the changes in the physical state of the drug in the implant induced by prolonged heat exposure had only a limited impact on system performance. However, for different drugs and polymers, changes in their physical state as a function of the heat exposure time might have more importance consequences. Careful monitoring of these kinetic aspects is recommended to assure desired product quality.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Matériaux Moléculaires et Thérapeutiques

Date de dépôt :

2022-10-13T08:57:24Z
2022-10-13T09:19:06Z
2022-10-25T07:05:34Z