Title :

Injection-molded capsule bodies and caps based on polymer blends for controlled drug delivery

Author(s) :

Benzine, Youcef [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Danede, Florence [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
willart, Jean-François [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
karrout, youness [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008

Journal title :

European Journal of Pharmaceutics and Biopharmaceutics

Abbreviated title :

European Journal of Pharmaceutics and Biopharmaceutics

Volume number :

168

Pages :

1-14

Publisher :

Elsevier BV

Publication date :

2021-11

ISSN :

0939-6411

English keyword(s) :

Injection-molding
Capsule shell
Controlled release
Polymer blend
Polyurethane

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

English abstract : [en]

A variety of polymer:polymer blends was used to prepare hot melt extrudates and empty capsules (bodies and caps) by injection-molding using a benchtop extruder (Babyplast). Kollidon SR:inulin and Carbothane:inulin blends ...
Show more >A variety of polymer:polymer blends was used to prepare hot melt extrudates and empty capsules (bodies and caps) by injection-molding using a benchtop extruder (Babyplast). Kollidon SR:inulin and Carbothane:inulin blends were investigated. The impact of the blend ratio on the water uptake and dry mass loss kinetics upon exposure to 0.1 M HCl, phosphate buffer pH 6.8 and culture medium optionally inoculated with fecal samples from Inflammatory Bowel Disease (IBD) patients were studied. Hot melt extrudates were loaded with up to 60 % theophylline, capsules were filled with drug powder. Increasing the inulin content led to increased water uptake and dry mass loss rates, resulting in accelerated drug release from the dosage forms, irrespective of the type of polymer blend. This can be attributed to the higher hydrophilicity/water-solubility of this polymer compared to Kollidon SR and Carbothane. Interestingly, the presence of fecal samples in culture medium increased the water uptake and dry mass loss of hot melt extrudates to a certain extent, suggesting partial system degradation by bacterial enzymes. However, these phenomena did not translate into any noteworthy impact of the presence of colonic bacteria on theophylline release from the investigated extrudates or capsules. Hence, drug release can be expected to be independent of the location “small intestine vs. colon” from these dosage forms, which can be advantageous for long term release throughout the entire gastro intestinal tract.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2022-10-13T09:02:34Z
2022-10-14T05:54:31Z