Pedal to the Metal: The Homogeneous Catalysis of the Native Chemical Ligation Reaction

Diemer, Vincent; Firstova, Olga; AGOURIDAS, Vangelis; Melnyk, Oleg

Document type :

Article dans une revue scientifique

DOI :

10.1002/chem.202104229

Title :

Pedal to the Metal: The Homogeneous Catalysis of the Native Chemical Ligation Reaction

Author(s) :

Diemer, Vincent [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Firstova, Olga [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
AGOURIDAS, Vangelis [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Centrale Lille
Melnyk, Oleg [Auteur]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Journal title :

Chemistry - A European Journal

Publisher :

Wiley-VCH Verlag

Publication date :

2022-03-16

ISSN :

0947-6539

HAL domain(s) :

Chimie

English abstract : [en]

The native chemical ligation reaction of peptide thioesters with cysteinyl peptides is a pivotal chemical process in the production of native or modified peptides and proteins, and well beyond in the preparation of various ...
Show more >The native chemical ligation reaction of peptide thioesters with cysteinyl peptides is a pivotal chemical process in the production of native or modified peptides and proteins, and well beyond in the preparation of various biomolecule analogs and materials. To benefit from this reaction at its fullest and to access all the possible applications, the experimentalist needs to know the factors affecting its rate and how to control it. This concept article presents the fundamental principles underlying the rate of the native chemical ligation and its homogeneous catalysis by nucleophiles. It has been prepared to serve as a quick guide in the search for an appropriate catalyst.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :