Title :

Synthesis and characterization of new 1,3,4-thiadiazole derivatives: study of their antibacterial activity and CT-DNA binding

Author(s) :

Sayiner, Hakan [Auteur]
Yilmazer, Mehmet [Auteur]
Abdelsalam, Aisha. [Auteur]
Ganim, Mohamed [Auteur]
Baloglu, Cengiz [Auteur]
Altunoglu, Yasemin Celik [Auteur]
Gür, Mahmut [Auteur]
Saracoglu, Murat [Auteur]
Erciyes University
Attia, Mohamed [Auteur]
Mahmoud, Safwat [Auteur]
Mohamed, Ekram [Auteur]
Boukherroub, Rabah [Auteur]
NanoBioInterfaces - IEMN [NBI - IEMN]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Al-Shaalan, Nora Hamad [Auteur]
Alharthi, Sarah [Auteur]
Taif University [TU]
Kandemirli, Fatma [Auteur correspondant]
Amin, Mohammed [Auteur]
Taif University [TU]

Journal title :

Rsc advances

Pages :

29627-29639

Publisher :

Royal Society of Chemistry

Publication date :

2022-10-17

ISSN :

2046-2069

HAL domain(s) :

Sciences de l'ingénieur [physics]

English abstract : [en]

1,3,4-Thiadiazole molecules (1–4) were synthesized by the reaction of phenylthiosemicarbazide and methoxy cinnamic acid molecules in the presence of phosphorus oxychloride, and characterized with UV, FT-IR, 13C-NMR, and ...
Show more >1,3,4-Thiadiazole molecules (1–4) were synthesized by the reaction of phenylthiosemicarbazide and methoxy cinnamic acid molecules in the presence of phosphorus oxychloride, and characterized with UV, FT-IR, 13C-NMR, and 1H-NMR methods. DFT calculations (b3lyp/6-311++G(d,p)) were performed to investigate the structures' geometry and physiochemical properties. Their antibacterial activity was screened for various bacteria strains such as Enterobacter aerogenes, Escherichia coli ATCC 13048, Salmonella kentucky, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus and Gram positive such as Staphylococcus aureus ATCC 25923, Listeria monocytogenes ATCC 7644, Enterococcus faecium, Enterococcus durans, Staphylococcus aureus ATCC, Serratia marcescens, Staphylococcus hominis, Staphylococcus epidermidis, alfa Streptococcus haemolyticus, Enterococcus faecium and found to have an inhibitory effect on Klebsiella pneumoniae and Staphylococcus hominis, while molecules 1, 3 and 4 had an inhibitory effect on Staphylococcus epidermidis and alpha Streptococcus haemolyticus. The experimental results were supported by the docking study using the Kinase ThiM from Klebsiella pneumoniae. All the investigated compounds showed an inhibitory effect for the Staphylococcus epidermidis protein. In addition, the mechanism of the 1–4 molecule interaction with calf thymus-DNA (CT-DNA) was investigated by UV-vis spectroscopic methods.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Source :

Harvested from HAL