Title :

Clonal haematopoiesis of indeterminate potential and cardiovascular events in systemic lupus erythematosus (HEMATOPLUS study)

Author(s) :

David, Clémence [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Duployez, Nicolas [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Eloy, Philippine [Auteur]
Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique [CIC 1425]
Université Paris Cité [UPCité]
Belhadi, Drifa [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Chezel, Julie [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Guern, Véronique Le [Auteur]
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)]
Laouénan, Cédric [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Fenwarth, Laurène [Auteur]
Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Rouzaud, Diane [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Centre de recherche sur l'Inflammation [CRI (UMR_S_1149 / ERL_8252 / U1149)]
Mathian, Alexis [Auteur]
Centre National de Référence du Lupus Systémique, Syndrome des Anticorps Anti-phospholipides et Maladies Auto-immunes Systémiques Rares [CHU Pitié Salpêtrière]
de Almeida Chaves, Sébastien [Auteur]
Duhaut, Pierre [Auteur]
Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 [MP3CV]
CHU Amiens-Picardie
Fain, Olivier [Auteur]
Service de médecine interne [CHU Saint-Antoine]
Galicier, Lionel [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Ghillani-Dalbin, Pascale [Auteur]
Service d'Immunologie [CHU Pitié-Salpétrière]
Kahn, Jean Emmanuel [Auteur]
Hôpital Ambroise Paré [AP-HP]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Morel, Nathalie [Auteur]
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)]
Perard, Laurent [Auteur]
Centre hospitalier Saint Joseph - Saint Luc [Lyon]
Pha, Micheline [Auteur]
Centre National de Référence du Lupus Systémique, Syndrome des Anticorps Anti-phospholipides et Maladies Auto-immunes Systémiques Rares [CHU Pitié Salpêtrière]
Sarrot-Reynauld, Francoise [Auteur]
Hôpital Michallon
Aumaitre, Olivier [Auteur]
Chasset, François [Auteur]
Limal, Nicolas [Auteur]
Desmurs-Clavel, Helene [Auteur]
Ackermann, Felix [Auteur]
Amoura, Zahir [Auteur]
Papo, Thomas [Auteur]
Preudhomme, Claude [Auteur]
Costedoat-Chalumeau, Nathalie [Auteur]
Sacre, Karim [Auteur]

Journal title :

Rheumatology

Pages :

4355-4363

Publisher :

Oxford University Press (OUP)

Publication date :

2022-11-01

ISSN :

1462-0324

English keyword(s) :

Cardiovascular Diseases/complications
Lupus Erythematosus
Systemic/complications
cardiovascular events
clonal haematopoiesis of indeterminate potential
Clonal Hematopoiesis
Female
Hematopoiesis/genetics
Humans
Male
Retrospective Studies

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie

English abstract : [en]

Abstract Objective The detection of somatic mutations among the genes of myeloid cells in asymptomatic patients—defining clonal haematopoiesis of indeterminate potential (CHIP)—is associated with a predisposition to ...
Show more >Abstract Objective The detection of somatic mutations among the genes of myeloid cells in asymptomatic patients—defining clonal haematopoiesis of indeterminate potential (CHIP)—is associated with a predisposition to cardiovascular events (CVEs) in the general population. We aimed to determine whether CHIP was associated with CVEs in SLE patients. Methods The study is an ancillary study of the randomized, double-blind, placebo-controlled, multicentre PLUS trial conducted from June 2007 through August 2010 at 37 centres in France, involving 573 SLE patients. The search for somatic mutations by high-throughput sequencing of 53 genes involved in clonal haematopoiesis was performed on genomic DNA collected at PLUS inclusion. CHIP prevalence was assessed in SLE and in a retrospective cohort of 479 patients free of haematological malignancy. The primary outcome was an incident CVE in SLE. Results Screening for CHIP was performed in 438 SLE patients [38 (29–47) years, 91.8% female]. Overall, 63 somatic mutations were identified in 47 patients, defining a CHIP prevalence of 10.7% in SLE. Most SLE patients (78.7%) carried a single mutation. Most variants (62.5%) were located in the DNMT3A gene. CHIP frequency was related to age and to age at SLE diagnosis, and was associated with a lower frequency of aPLs. CHIP occurred >20 years earlier (P < 0.00001) in SLE than in controls. The detection of CHIP at inclusion was not found to be associated with occurrence of CVEs during follow-up [HR = 0.42 (0.06–3.21), P = 0.406]. Conclusion The prevalence of CHIP is relatively high in SLE for a given age, but was not found to be associated with incident CVEs. Trial registration ClinicalTrials.gov, https://clinicaltrials.gov, NCT05146414.Show less >

Language :

Anglais

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL