Title :

[Review] Host miRNAs as biomarkers of SARS-CoV-2 infection: a critical review

Author(s) :

Pollet, Kato [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610 [Laboratoire de Virologie]
Garnier, Nathalie [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610 [Laboratoire de Virologie]
Szunerits, Sabine [Auteur]
NanoBioInterfaces - IEMN [NBI - IEMN]
Madder, Annemieke [Auteur]
Universiteit Gent = Ghent University [UGENT]
Hober, Didier [Auteur]
Pathogenèse virale du diabète de type 1 - ULR 3610 [Laboratoire de Virologie]
Engelmann, Ilka [Auteur correspondant]
Pathogenèse virale du diabète de type 1 - ULR 3610 [Laboratoire de Virologie]

Journal title :

Sensors & Diagnostics

Pages :

12-35

Publisher :

Royal Society of Chemistry

Publication date :

2023-01

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Génomique, Transcriptomique et Protéomique [q-bio.GN]
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies émergentes
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Virologie

English abstract : [en]

MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, have received increasing attention as potential biomarkers of different diseases, including viral infections. Severe acute respiratory syndrome ...
Show more >MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, have received increasing attention as potential biomarkers of different diseases, including viral infections. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the disease it is causing, coronavirus disease (COVID-19), has affected health, society and life worldwide since its pandemic spread. Differential expression of miRNAs in COVID-19 patients compared to healthy controls and also between different severity grades of COVID-19 has been described in several recent studies. In this review, we discuss in detail studies that investigated miRNA expression in body fluids of COVID-19 patients. Several studies found a different miRNA expression profile in COVID-19 patients compared to controls but also in different severity grades of the disease. We compared the main findings of the studies in order to identify miRNAs that have been identified as differentially expressed by more than one study and could serve as diagnostic or prognostic biomarkers of COVID-19. Finally, we highlight the challenges and perspectives associated to the use of miRNAs as biomarkers of COVID-19.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Source :

Harvested from HAL