Folate-based radiotracers for nuclear ...
Document type :
Compte-rendu et recension critique d'ouvrage
Title :
Folate-based radiotracers for nuclear imaging and radionuclide therapy
Author(s) :
Wagner, Laurène [Auteur]
Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Kenzhebayeva, Bibigul [Auteur]
Satbayev University
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Dhaini, Batoul [Auteur]
الجامعة اللبنانية [بيروت] = Lebanese University [Beirut] = Université libanaise [Beyrouth] [LU / ULB]
Laboratoire Réactions et Génie des Procédés [LRGP]
Boukhlef, Samir [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Moussaron, Albert [Auteur]
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Laboratoire Réactions et Génie des Procédés [LRGP]
Mordon, Serge [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Frochot, Céline [Auteur]
Laboratoire Réactions et Génie des Procédés [LRGP]
Collet, Charlotte [Auteur]
Imagerie Adaptative Diagnostique et Interventionnelle [IADI]
Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire
Acherar, Samir [Auteur]
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Kenzhebayeva, Bibigul [Auteur]
Satbayev University
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Dhaini, Batoul [Auteur]
الجامعة اللبنانية [بيروت] = Lebanese University [Beirut] = Université libanaise [Beyrouth] [LU / ULB]
Laboratoire Réactions et Génie des Procédés [LRGP]
Boukhlef, Samir [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Moussaron, Albert [Auteur]
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Laboratoire Réactions et Génie des Procédés [LRGP]
Mordon, Serge [Auteur]

Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Frochot, Céline [Auteur]
Laboratoire Réactions et Génie des Procédés [LRGP]
Collet, Charlotte [Auteur]
Imagerie Adaptative Diagnostique et Interventionnelle [IADI]
Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire
Acherar, Samir [Auteur]
Laboratoire de Chimie Physique Macromoléculaire [LCPM]
Journal title :
Coordination Chemistry Reviews
Pages :
214702
Publisher :
Elsevier
Publication date :
2022-11-01
ISSN :
0010-8545
English keyword(s) :
Folic acid
Ovarian cancer
Radiopharmaceutical
Nuclear imaging
Targeted radionuclide therapy
Theranostic
Ovarian cancer
Radiopharmaceutical
Nuclear imaging
Targeted radionuclide therapy
Theranostic
HAL domain(s) :
Chimie/Radiochimie
English abstract : [en]
Folate receptor α (FRα) is overexpressed on numerous tumorous cell types such as ovarian or endometrial cancer cells. Moreover, FRα is absent from most healthy tissues as it is normally expressed only on the surface of ...
Show more >Folate receptor α (FRα) is overexpressed on numerous tumorous cell types such as ovarian or endometrial cancer cells. Moreover, FRα is absent from most healthy tissues as it is normally expressed only on the surface of proximal tubules cells of kidneys and choroid plexus. Thus, folate-based radiopharmaceuticals have emerged this last two decades as FRα is a target of choice to diagnose and treat numerous cancers. Nuclear imaging is a performing diagnostic technology using highly sensitive detectors and specific radiopharmaceuticals used to detect tumors at an earlier stage. Herein, an overview of the development of folate-based radiopharmaceuticals to detect FRα-positive tumors by nuclear imaging using positron emission tomography (PET) and single photon emission computed tomography (SPECT) is exposed. Strategies developed to improve precursor synthesis, bioavailability, clearance, and affinity to FRα will be detailed. Advances made to decrease kidney uptake open the gate to targeted radionuclide therapy (TRT) using folate-based radiopharmaceuticals to treat FRα-positive tumors. Thus, radiofolates used in TRT and more precisely in a theranostic approach will be depicted in this reviewShow less >
Show more >Folate receptor α (FRα) is overexpressed on numerous tumorous cell types such as ovarian or endometrial cancer cells. Moreover, FRα is absent from most healthy tissues as it is normally expressed only on the surface of proximal tubules cells of kidneys and choroid plexus. Thus, folate-based radiopharmaceuticals have emerged this last two decades as FRα is a target of choice to diagnose and treat numerous cancers. Nuclear imaging is a performing diagnostic technology using highly sensitive detectors and specific radiopharmaceuticals used to detect tumors at an earlier stage. Herein, an overview of the development of folate-based radiopharmaceuticals to detect FRα-positive tumors by nuclear imaging using positron emission tomography (PET) and single photon emission computed tomography (SPECT) is exposed. Strategies developed to improve precursor synthesis, bioavailability, clearance, and affinity to FRα will be detailed. Advances made to decrease kidney uptake open the gate to targeted radionuclide therapy (TRT) using folate-based radiopharmaceuticals to treat FRα-positive tumors. Thus, radiofolates used in TRT and more precisely in a theranostic approach will be depicted in this reviewShow less >
Language :
Anglais
Popular science :
Non
Source :
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