ALGINATE versus negative-pressure therapy: ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
ALGINATE versus negative-pressure therapy: Comparison of the clinical effectiveness, tolerance and costs in management of patients after surgical excision. Multicenter, randomized non-inferiority clinical trial on 113 patients
Auteur(s) :
Guerreschi, Pierre [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Casanova, D. [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Maunoury, F. [Auteur]
Sinna, R. [Auteur]
CHU Amiens-Picardie
Revol, M. [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Advanced Drug Delivery Systems (ADDS) - U1008
Casanova, D. [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Maunoury, F. [Auteur]
Sinna, R. [Auteur]
CHU Amiens-Picardie
Revol, M. [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Titre de la revue :
Annales de Chirurgie Plastique Esthétique
Nom court de la revue :
Ann Chir Plast Esthet
Numéro :
66
Pagination :
3-9
Éditeur :
Elsevier
Date de publication :
2020-12-08
ISSN :
1768-319X
Mot(s)-clé(s) :
Calcium alginate dressing
Negative Pressure Wound Therapy
Skin excision
Cost of patient care
Negative Pressure Wound Therapy
Skin excision
Cost of patient care
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Introduction
Pure calcium alginate dressing (ALGINATE) and Negative Pressure Wound Therapy (NPWT) are frequently used for the preparation of skin excisions for a split thickness skin graft take. The trial compared the ...
Lire la suite >Introduction Pure calcium alginate dressing (ALGINATE) and Negative Pressure Wound Therapy (NPWT) are frequently used for the preparation of skin excisions for a split thickness skin graft take. The trial compared the healing efficacy, safety and cost of patient care for these two treatments. Patients and methods This randomized, non-inferiority trial enrolled 113 patients who underwent skin excision (> 30 cm2) and received ALGINATE or NPWT. The primary outcome was the time to obtain optimal granulation tissue for a split thickness skin graft take. Secondary outcomes were the occurrence of adverse events (AEs) and the impact of the patient care cost on the Social Security budget. Results The mean time to optimal granulation was similar between ALGINATE and NPWT: approximately 20 days. No AE was reported with ALGINATE while 24 % of patients treated with NPWT presented an AE. Following hospitalization, 94 % of ALGINATE patients were cared for at home by a private nurse, while 90 % of NPWT patients were followed up in aftercare and rehabilitation facilities or home hospitalization. Therefore, the cost of treatment per patient for the French Social Security was 498 € with ALGINATE and 2104 € with NPWT. Conclusion This trial has demonstrated that ALGINATE has a similar healing efficacy to that of NPWT, and that it is markedly better with regard to patient safety and cost savings. ALGINATE should therefore be preferred to NPWT in this indication.Lire moins >
Lire la suite >Introduction Pure calcium alginate dressing (ALGINATE) and Negative Pressure Wound Therapy (NPWT) are frequently used for the preparation of skin excisions for a split thickness skin graft take. The trial compared the healing efficacy, safety and cost of patient care for these two treatments. Patients and methods This randomized, non-inferiority trial enrolled 113 patients who underwent skin excision (> 30 cm2) and received ALGINATE or NPWT. The primary outcome was the time to obtain optimal granulation tissue for a split thickness skin graft take. Secondary outcomes were the occurrence of adverse events (AEs) and the impact of the patient care cost on the Social Security budget. Results The mean time to optimal granulation was similar between ALGINATE and NPWT: approximately 20 days. No AE was reported with ALGINATE while 24 % of patients treated with NPWT presented an AE. Following hospitalization, 94 % of ALGINATE patients were cared for at home by a private nurse, while 90 % of NPWT patients were followed up in aftercare and rehabilitation facilities or home hospitalization. Therefore, the cost of treatment per patient for the French Social Security was 498 € with ALGINATE and 2104 € with NPWT. Conclusion This trial has demonstrated that ALGINATE has a similar healing efficacy to that of NPWT, and that it is markedly better with regard to patient safety and cost savings. ALGINATE should therefore be preferred to NPWT in this indication.Lire moins >
Langue :
Anglais
Français
Français
Audience :
Internationale
Établissement(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Date de dépôt :
2022-12-08T01:33:36Z
2023-02-22T09:58:55Z
2023-02-22T11:52:58Z
2023-02-22T09:58:55Z
2023-02-22T11:52:58Z