Title :

In vitro evaluation of antibacterial activity of a plant extract-loaded wound dressing

Author(s) :

Diop, M. [Auteur]
Thioune, O. [Auteur]
Université Cheikh Anta Diop [Dakar, Sénégal] [UCAD]
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Maton, Mickael [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Riviere, Celine [Auteur]
Transfrontalière BioEcoAgro - UMR 1158 [BioEcoAgro]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Mahieux, Séverine [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Roumy, Vincent [Auteur]
Institut Charles Viollette (ICV) - ULR 7394
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008

Journal title :

Journal of Drug Delivery Science and Technology

Abbreviated title :

J. Drug Deliv. Sci. Technol.

Volume number :

67

Publication date :

2022-05-11

ISSN :

1773-2247

Keyword(s) :

Wound dressing
Cyclodextrins
Antibacterial activity
Co-products
Plant extracts

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

This study reports the in vitro efficacy of a mixture of plant extracts used as antibacterial agents loaded in a dressing to prevent infection in a wound. These natural compounds were extracted from avocado and mango. A ...
Show more >This study reports the in vitro efficacy of a mixture of plant extracts used as antibacterial agents loaded in a dressing to prevent infection in a wound. These natural compounds were extracted from avocado and mango. A mixture of equal proportions of petroleum ether extract from avocado kernels and methanolic extract from mango kernels was effective on the majority of 36 bacterial strains and presented excellent results against S. aureus. The Minimal Inhibitory Concentrations (MIC) measured on Staphylococcus aureus (ATCC 6538) were 0.019 mg/mL for the mixture compared to 0.039 mg/mL for the avocado or mango extract alone. This mixture was incorporated into a wound dressing composed of non-woven fabric and a gel. This gel consists of a plasticizer (starch/glycerin) and an absorbent (CMC/PCD) and is designed to have swelling properties and entrap plant extract. A formulation containing equal proportions of CMC and PCD enabled us to obtain 800% of swelling and a good adhesion of the gel to the non-woven fabric. The final dressing containing the mixture of avocado and mango extracts presented excellent antibacterial activity against S. aureus. Microbiological tests demonstrated that a wound dressing loaded with avocado/mango seed extract induced additional bacterial reduction of 3 Log10 and 2 Log10 against S. aureus and P. aeruginosa respectively but no additional bacterial reduction of C. albicans compared to the control. Our study demonstrated the scope for interest in plant species extracts provided by agricultural co-products in developing a new antibacterial wound dressing.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Institut Charles Viollette (ICV) - ULR 7394
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2022-12-08T02:07:44Z
2023-02-15T13:45:50Z