Comparison of Endoscopic Dilatation and ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Comparison of Endoscopic Dilatation and Heller's Myotomy for Treating Esophageal Achalasia in Children: A Multicenter Study.
Author(s) :
Nicolas, Audrey [Auteur]
CHU Limoges
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Aumar, Madeleine [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Tran, Léa [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Tiret, Alice [Auteur]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Duclaux-Loras, Rémi [Auteur]
Service d'Hépatologie et de Gastroentérologie [Lyon]
Bridoux-Henno, Laure [Auteur]
Hôpital Sud [CHU Rennes]
Campeotto, Florence [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Fabre, Alexandre [Auteur]
Génétique Médicale et Génomique Fonctionnelle [GMGF]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Breton, Anne [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Languepin, Jeanne [Auteur]
CHU Limoges
Kyheng, MaÉva [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Viala, Jérôme [Auteur]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Coopman, Stéphanie [Auteur]
Hôpital Jeanne de Flandres
gottrand, frederic [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
CHU Limoges
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Aumar, Madeleine [Auteur]

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Tran, Léa [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE (Ex-Liric)]
Tiret, Alice [Auteur]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Duclaux-Loras, Rémi [Auteur]
Service d'Hépatologie et de Gastroentérologie [Lyon]
Bridoux-Henno, Laure [Auteur]
Hôpital Sud [CHU Rennes]
Campeotto, Florence [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Fabre, Alexandre [Auteur]
Génétique Médicale et Génomique Fonctionnelle [GMGF]
Hôpital de la Timone [CHU - APHM] [TIMONE]
Breton, Anne [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Languepin, Jeanne [Auteur]
CHU Limoges
Kyheng, MaÉva [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Viala, Jérôme [Auteur]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Coopman, Stéphanie [Auteur]
Hôpital Jeanne de Flandres
gottrand, frederic [Auteur]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Journal title :
The Journal of Pediatrics
Abbreviated title :
J Pediatr
Volume number :
251
Pages :
134-139.e2
Publication date :
2022-07-13
ISSN :
1097-6833
English keyword(s) :
Child
Male
Humans
Female
Heller Myotomy
Esophageal Achalasia
Dilatation
Retrospective Studies
Endoscopy
Heller's myotomy
achalasia
children
endoscopic dilatation
Male
Humans
Female
Heller Myotomy
Esophageal Achalasia
Dilatation
Retrospective Studies
Endoscopy
Heller's myotomy
achalasia
children
endoscopic dilatation
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
To compare the efficacy of, and complications from, the 2 main treatments for achalasia: endoscopic dilatation and surgical cardiomyotomy (Heller's myotomy). We retrospectively collected data on children treated for achalasia ...
Show more >To compare the efficacy of, and complications from, the 2 main treatments for achalasia: endoscopic dilatation and surgical cardiomyotomy (Heller's myotomy). We retrospectively collected data on children treated for achalasia over an 11-year period from 8 tertiary pediatric centers. A line of treatment was defined as performing either Heller's myotomy or 1-3 sessions of endoscopy dilatation over 3 months. Treatment success was a priori defined as clinical improvement and no need for new treatment. Ninety-seven children (median age, 12 years; 57% boys) were included. The median time to diagnosis was 10.5 months, and the median follow-up period was 27 months. Thirty-seven children were treated by Heller's myotomy and 60 by endoscopy dilatation as the first-line treatment. After adjustment for potentially confounding factors, Heller's myotomy was significantly more successful than endoscopy dilatation (hazard ratio, 3.93 [1.74; 8.88]; P = .001), with a median survival without failure of 49 and 7 months, respectively, and with no significant difference in the occurrence of complications (35.2% for Heller's myotomy, 29.7% for endoscopy dilatation, P = .56). Hydrostatic dilatation was as successful as pneumatic dilatation (hazard ratio, 1.35 [0.56; 3.23]; P = .50). Heller's myotomy is more successful than endoscopy dilatation, with no significant difference in the occurrence of serious complications. This raises the potential role of peroral endoscopic myotomy as an alternative treatment to Heller's myotomy.Show less >
Show more >To compare the efficacy of, and complications from, the 2 main treatments for achalasia: endoscopic dilatation and surgical cardiomyotomy (Heller's myotomy). We retrospectively collected data on children treated for achalasia over an 11-year period from 8 tertiary pediatric centers. A line of treatment was defined as performing either Heller's myotomy or 1-3 sessions of endoscopy dilatation over 3 months. Treatment success was a priori defined as clinical improvement and no need for new treatment. Ninety-seven children (median age, 12 years; 57% boys) were included. The median time to diagnosis was 10.5 months, and the median follow-up period was 27 months. Thirty-seven children were treated by Heller's myotomy and 60 by endoscopy dilatation as the first-line treatment. After adjustment for potentially confounding factors, Heller's myotomy was significantly more successful than endoscopy dilatation (hazard ratio, 3.93 [1.74; 8.88]; P = .001), with a median survival without failure of 49 and 7 months, respectively, and with no significant difference in the occurrence of complications (35.2% for Heller's myotomy, 29.7% for endoscopy dilatation, P = .56). Hydrostatic dilatation was as successful as pneumatic dilatation (hazard ratio, 1.35 [0.56; 3.23]; P = .50). Heller's myotomy is more successful than endoscopy dilatation, with no significant difference in the occurrence of serious complications. This raises the potential role of peroral endoscopic myotomy as an alternative treatment to Heller's myotomy.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2022-12-14T09:42:15Z
2022-12-14T09:44:30Z
2022-12-14T13:49:38Z
2022-12-14T14:01:20Z
2022-12-14T14:32:52Z
2022-12-14T16:11:06Z
2022-12-16T12:00:54Z
2022-12-14T09:44:30Z
2022-12-14T13:49:38Z
2022-12-14T14:01:20Z
2022-12-14T14:32:52Z
2022-12-14T16:11:06Z
2022-12-16T12:00:54Z
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