Oleic Acid and Palmitic Acid from Bacteroides ...
Document type :
Article dans une revue scientifique: Article original
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Title :
Oleic Acid and Palmitic Acid from Bacteroides thetaiotaomicron and Lactobacillus johnsonii Exhibit Anti-Inflammatory and Antifungal Properties
Author(s) :
Charlet, Rogatien [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Faculté de Médecine Henri Warembourg - Université de Lille
Institut National de la Santé et de la Recherche Médicale [INSERM]
Le Danvic, Chrystelle [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Sendid, Boualem [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Faculté de Médecine Henri Warembourg - Université de Lille
Institut National de la Santé et de la Recherche Médicale [INSERM]
Nagnan-Le Meillour, Patricia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Jawhara, Samir [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Faculté de Médecine Henri Warembourg - Université de Lille
Institut National de la Santé et de la Recherche Médicale [INSERM]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Faculté de Médecine Henri Warembourg - Université de Lille
Institut National de la Santé et de la Recherche Médicale [INSERM]
Le Danvic, Chrystelle [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Sendid, Boualem [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Faculté de Médecine Henri Warembourg - Université de Lille
Institut National de la Santé et de la Recherche Médicale [INSERM]
Nagnan-Le Meillour, Patricia [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Jawhara, Samir [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Faculté de Médecine Henri Warembourg - Université de Lille
Institut National de la Santé et de la Recherche Médicale [INSERM]
Journal title :
Microorganisms
Abbreviated title :
Microorganisms
Volume number :
10
Pages :
1803
Publisher :
MDPI AG
Publication date :
2022-09-08
ISSN :
2076-2607
English keyword(s) :
colitis
fatty acids
oleic acid
palmitic acid
inflammatory response
dextran sulfate sodium
Candida glabrata
Bacteroides thetaiotaomicron
Lactobacillus johnsonii
fungal overgrowth
fatty acids
oleic acid
palmitic acid
inflammatory response
dextran sulfate sodium
Candida glabrata
Bacteroides thetaiotaomicron
Lactobacillus johnsonii
fungal overgrowth
HAL domain(s) :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
English abstract : [en]
A decrease in populations of Bacteroides thetaiotaomicron and Lactobacillus johnsonii is observed during the development of colitis and fungal overgrowth, while restoration of these populations reduces inflammatory parameters ...
Show more >A decrease in populations of Bacteroides thetaiotaomicron and Lactobacillus johnsonii is observed during the development of colitis and fungal overgrowth, while restoration of these populations reduces inflammatory parameters and fungal overgrowth in mice. This study investigated the effect of two fatty acids from B. thetaiotaomicron and L. johnsonii on macrophages and Caco-2 cells, as well as their impact on the inflammatory immune response and on Candida glabrata overgrowth in a murine model of dextran sulfate sodium (DSS)-induced colitis. Oleic acid (OA) and palmitic acid (PA) from L. johnsonii and B. thetaiotaomicron were detected during their interaction with epithelial cells from colon samples. OA alone or OA combined with PA (FAs) reduced the expression of proinflammatory mediators in intestinal epithelial Caco-2 cells challenged with DSS. OA alone or FAs increased FFAR1, FFAR2, AMPK, and IL-10 expression in macrophages. Additionally, OA alone or FAs decreased COX-2, TNFα, IL-6, and IL-12 expression in LPS-stimulated macrophages. In the DSS murine model, oral administration of FAs reduced inflammatory parameters, decreased Escherichia coli and Enterococcus faecalis populations, and eliminated C. glabrata from the gut. Overall, these findings provide evidence that OA combined with PA exhibits anti-inflammatory and antifungal properties.Show less >
Show more >A decrease in populations of Bacteroides thetaiotaomicron and Lactobacillus johnsonii is observed during the development of colitis and fungal overgrowth, while restoration of these populations reduces inflammatory parameters and fungal overgrowth in mice. This study investigated the effect of two fatty acids from B. thetaiotaomicron and L. johnsonii on macrophages and Caco-2 cells, as well as their impact on the inflammatory immune response and on Candida glabrata overgrowth in a murine model of dextran sulfate sodium (DSS)-induced colitis. Oleic acid (OA) and palmitic acid (PA) from L. johnsonii and B. thetaiotaomicron were detected during their interaction with epithelial cells from colon samples. OA alone or OA combined with PA (FAs) reduced the expression of proinflammatory mediators in intestinal epithelial Caco-2 cells challenged with DSS. OA alone or FAs increased FFAR1, FFAR2, AMPK, and IL-10 expression in macrophages. Additionally, OA alone or FAs decreased COX-2, TNFα, IL-6, and IL-12 expression in LPS-stimulated macrophages. In the DSS murine model, oral administration of FAs reduced inflammatory parameters, decreased Escherichia coli and Enterococcus faecalis populations, and eliminated C. glabrata from the gut. Overall, these findings provide evidence that OA combined with PA exhibits anti-inflammatory and antifungal properties.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Research team(s) :
Glycobiology in fungal Pathogenesis and Clinical Applications
Glycobiologie de l’olfaction
Glycobiologie de l’olfaction
Submission date :
2023-01-18T09:29:32Z
2023-01-18T15:54:44Z
2023-01-18T15:54:44Z
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