Oleic Acid and Palmitic Acid from Bacteroides ...
Type de document :
Article dans une revue scientifique: Article original
URL permanente :
Titre :
Oleic Acid and Palmitic Acid from Bacteroides thetaiotaomicron and Lactobacillus johnsonii Exhibit Anti-Inflammatory and Antifungal Properties
Auteur(s) :
Charlet, Rogatien [Auteur]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Faculté de Médecine Henri Warembourg - Université de Lille
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Le Danvic, Chrystelle [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Sendid, Boualem [Auteur]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Faculté de Médecine Henri Warembourg - Université de Lille
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Nagnan-Le Meillour, Patricia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Jawhara, Samir [Auteur]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Faculté de Médecine Henri Warembourg - Université de Lille
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Institut National de la Santé et de la Recherche Médicale [INSERM]
Faculté de Médecine Henri Warembourg - Université de Lille
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Le Danvic, Chrystelle [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Sendid, Boualem [Auteur]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Faculté de Médecine Henri Warembourg - Université de Lille
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Nagnan-Le Meillour, Patricia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Jawhara, Samir [Auteur]
Institut National de la Santé et de la Recherche Médicale [INSERM]
Faculté de Médecine Henri Warembourg - Université de Lille
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Titre de la revue :
Microorganisms
Nom court de la revue :
Microorganisms
Numéro :
10
Pagination :
1803
Éditeur :
MDPI AG
Date de publication :
2022-09-08
ISSN :
2076-2607
Mot(s)-clé(s) en anglais :
colitis
fatty acids
oleic acid
palmitic acid
inflammatory response
dextran sulfate sodium
Candida glabrata
Bacteroides thetaiotaomicron
Lactobacillus johnsonii
fungal overgrowth
fatty acids
oleic acid
palmitic acid
inflammatory response
dextran sulfate sodium
Candida glabrata
Bacteroides thetaiotaomicron
Lactobacillus johnsonii
fungal overgrowth
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Chimie/Chimie théorique et/ou physique
Résumé en anglais : [en]
A decrease in populations of Bacteroides thetaiotaomicron and Lactobacillus johnsonii is observed during the development of colitis and fungal overgrowth, while restoration of these populations reduces inflammatory parameters ...
Lire la suite >A decrease in populations of Bacteroides thetaiotaomicron and Lactobacillus johnsonii is observed during the development of colitis and fungal overgrowth, while restoration of these populations reduces inflammatory parameters and fungal overgrowth in mice. This study investigated the effect of two fatty acids from B. thetaiotaomicron and L. johnsonii on macrophages and Caco-2 cells, as well as their impact on the inflammatory immune response and on Candida glabrata overgrowth in a murine model of dextran sulfate sodium (DSS)-induced colitis. Oleic acid (OA) and palmitic acid (PA) from L. johnsonii and B. thetaiotaomicron were detected during their interaction with epithelial cells from colon samples. OA alone or OA combined with PA (FAs) reduced the expression of proinflammatory mediators in intestinal epithelial Caco-2 cells challenged with DSS. OA alone or FAs increased FFAR1, FFAR2, AMPK, and IL-10 expression in macrophages. Additionally, OA alone or FAs decreased COX-2, TNFα, IL-6, and IL-12 expression in LPS-stimulated macrophages. In the DSS murine model, oral administration of FAs reduced inflammatory parameters, decreased Escherichia coli and Enterococcus faecalis populations, and eliminated C. glabrata from the gut. Overall, these findings provide evidence that OA combined with PA exhibits anti-inflammatory and antifungal properties.Lire moins >
Lire la suite >A decrease in populations of Bacteroides thetaiotaomicron and Lactobacillus johnsonii is observed during the development of colitis and fungal overgrowth, while restoration of these populations reduces inflammatory parameters and fungal overgrowth in mice. This study investigated the effect of two fatty acids from B. thetaiotaomicron and L. johnsonii on macrophages and Caco-2 cells, as well as their impact on the inflammatory immune response and on Candida glabrata overgrowth in a murine model of dextran sulfate sodium (DSS)-induced colitis. Oleic acid (OA) and palmitic acid (PA) from L. johnsonii and B. thetaiotaomicron were detected during their interaction with epithelial cells from colon samples. OA alone or OA combined with PA (FAs) reduced the expression of proinflammatory mediators in intestinal epithelial Caco-2 cells challenged with DSS. OA alone or FAs increased FFAR1, FFAR2, AMPK, and IL-10 expression in macrophages. Additionally, OA alone or FAs decreased COX-2, TNFα, IL-6, and IL-12 expression in LPS-stimulated macrophages. In the DSS murine model, oral administration of FAs reduced inflammatory parameters, decreased Escherichia coli and Enterococcus faecalis populations, and eliminated C. glabrata from the gut. Overall, these findings provide evidence that OA combined with PA exhibits anti-inflammatory and antifungal properties.Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
CNRS
Équipe(s) de recherche :
Glycobiology in fungal Pathogenesis and Clinical Applications
Glycobiologie de l’olfaction
Glycobiologie de l’olfaction
Date de dépôt :
2023-01-18T09:29:32Z
2023-01-18T15:54:44Z
2023-01-18T15:54:44Z
Fichiers
- P22.44 Samir Jawhara - Microorganisms2 2022.pdf
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