Titre :

WHEN RESIDUAL WATER INFLUENCES THE COCRYSTALLIZATION OUTPUT: THE CARBAMAZEPINE AND TARTARIC ACID CASE

Auteur(s) :

Roca Paixao, Luisa-Viviane [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Danede, Florence [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
T. Correia, Natália [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Affouard, Frédéric [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Titre de la manifestation scientifique :

Journées SolvATE 2021

Ville :

Lille

Pays :

France

Date de début de la manifestation scientifique :

2021-12-09

Discipline(s) HAL :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

Résumé en anglais : [en]

The design of poorly water-soluble pharmaceutical molecules using cocrystallization has drawn increasing interest as these new materials can be used in order to improve their dissolution rate, aqueous solubility, ...
Lire la suite >The design of poorly water-soluble pharmaceutical molecules using cocrystallization has drawn increasing interest as these new materials can be used in order to improve their dissolution rate, aqueous solubility, bioavailability and/or hygroscopicity. Different synthesis techniques can be used in order to obtain cocrystals such as crystallization from solution, neat and liquid-assisted grinding (LAG), among many others. In this work, the impact of residual water in the final cocrystallization product has been investigated by using two different synthesis techniques, solution evaporation and liquid assisted grinding. For this purpose, previously published systems were studied: carbamazepine with L-tartaric acid and carbamazepine with DL-tartaric acid. From these systems, two different cocrystals were obtained and characterized by using their thermal and structural behaviour. On one hand, the crystalline structure resolution of one of the cocrystals shows the obtention of an ordered system with an exact molar ratio. On the other hand, a known cocrystal, described as a coformer channel-filled structure with an unknown molar ratio, was thoroughly investigated to determine the molar ratio. During this study, the influence (or lack of) of residual water on these systems was shown to be dependent on the obtained cocrystal as well as the chosen synthesis method and to have a great impact on the cocrystallization output.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
INRAE
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Matériaux Moléculaires et Thérapeutiques

Date de dépôt :

2023-01-29T10:22:14Z
2023-02-02T13:50:57Z