A New Synergistic Strategy for Virus and ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
A New Synergistic Strategy for Virus and Bacteria Eradication: Towards Universal Disinfectants
Auteur(s) :
Leclercq, Loïc [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Rataj, Véronique [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Rataj, Véronique [Auteur]

Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Titre de la revue :
Pharmaceutics
Numéro :
14
Date de publication :
2022-12-28
ISSN :
1999-4923
Mot(s)-clé(s) :
didecyldimethylammonium chloride
N
N-bis(3-aminopropyl)dodecylamine
cyclodextrin
bactericide
virucide
poliovirus
norovirus
Pseudomonas aeruginosa
synergistic formulation
N
N-bis(3-aminopropyl)dodecylamine
cyclodextrin
bactericide
virucide
poliovirus
norovirus
Pseudomonas aeruginosa
synergistic formulation
Discipline(s) HAL :
Chimie/Chimie organique
Résumé en anglais : [en]
In response to the COVID-19 and monkeypox outbreaks, we present the development of a universal disinfectant to avoid the spread of infectious viral diseases through contact with contaminated surfaces. The sanitizer, based ...
Lire la suite >In response to the COVID-19 and monkeypox outbreaks, we present the development of a universal disinfectant to avoid the spread of infectious viral diseases through contact with contaminated surfaces. The sanitizer, based on didecyldimethylammonium chloride (DDAC), N,N-bis(3-aminopropyl)dodecylamine (APDA) and γ-cyclodextrin (γ-CD), shows synergistic effects against non-enveloped viruses (poliovirus type 1 and murine norovirus) according to the EN 14476 standard (≥99.99% reduction of virus titer). When a disinfectant product is effective against them, it can be considered that it will be effective against all types of viruses, including enveloped viruses. Consequently, “general virucidal activity” can be claimed. Moreover, we have extended this synergistic action to bacteria (P. aeruginosa, EN 13727). Based on physicochemical investigations, we have proposed two independent mechanisms of action against bacteria and non-enveloped viruses, operating at sub- and super-micellar concentrations, respectively. This synergistic mixture could then be highly helpful as a universal disinfectant to avoid the spread of infectious viral or bacterial diseases in community settings, including COVID-19 and monkeypox (caused by enveloped viruses).Lire moins >
Lire la suite >In response to the COVID-19 and monkeypox outbreaks, we present the development of a universal disinfectant to avoid the spread of infectious viral diseases through contact with contaminated surfaces. The sanitizer, based on didecyldimethylammonium chloride (DDAC), N,N-bis(3-aminopropyl)dodecylamine (APDA) and γ-cyclodextrin (γ-CD), shows synergistic effects against non-enveloped viruses (poliovirus type 1 and murine norovirus) according to the EN 14476 standard (≥99.99% reduction of virus titer). When a disinfectant product is effective against them, it can be considered that it will be effective against all types of viruses, including enveloped viruses. Consequently, “general virucidal activity” can be claimed. Moreover, we have extended this synergistic action to bacteria (P. aeruginosa, EN 13727). Based on physicochemical investigations, we have proposed two independent mechanisms of action against bacteria and non-enveloped viruses, operating at sub- and super-micellar concentrations, respectively. This synergistic mixture could then be highly helpful as a universal disinfectant to avoid the spread of infectious viral or bacterial diseases in community settings, including COVID-19 and monkeypox (caused by enveloped viruses).Lire moins >
Langue :
Anglais
Comité de lecture :
Oui
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CNRS
Centrale Lille
ENSCL
Univ. Artois
CNRS
Centrale Lille
ENSCL
Univ. Artois
Collections :
Équipe(s) de recherche :
Colloïdes catalyse oxydation (CÏSCO)
Date de dépôt :
2023-03-09T01:21:54Z
2023-03-24T09:41:27Z
2023-03-24T09:41:27Z
Fichiers
- pharmaceutics-14-02791-v2.pdf
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