Titre :

In Vitro and In Vivo Evaluation of a Bio-Inspired Adhesive for Bone Fixation.

Auteur(s) :

Schlund, Matthias [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Dartus, Julien [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Defrancois, Sarah [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Ferri, Joel [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Delattre, Jérôme [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Woisel, Patrice [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Lyskawa, Joel [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207
Chai, Feng [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]

Titre de la revue :

Pharmaceutics

Numéro :

15

Pagination :

1233

Éditeur :

MDPI

Date de publication :

2023-04-29

ISSN :

1999-4923

Mot(s)-clé(s) :

bone glue
bone fixation
animal model
bioresorbable adhesive
bone adhesive

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Compared to metallic hardware, an effective bone adhesive can revolutionize the treatment of clinically challenging situations such as comminuted, articular, and pediatric fractures. The present study aims to develop such ...
Lire la suite >Compared to metallic hardware, an effective bone adhesive can revolutionize the treatment of clinically challenging situations such as comminuted, articular, and pediatric fractures. The present study aims to develop such a bio-inspired bone adhesive, based upon a modified mineral-organic adhesive with tetracalcium phosphate (TTCP) and phosphoserine (OPS) by incorporating nanoparticles of polydopamine (nPDA). The optimal formulation, which was screened using in vitro instrumental tensile adhesion tests, was found to be 50%molTTCP/50%molOPS-2%wtnPDA with a liquid-to-powder ratio of 0.21 mL/g. This adhesive has a substantially stronger adhesive strength (1.0–1.6 MPa) to bovine cortical bone than the adhesive without nPDA (0.5–0.6 MPa). To simulate a clinical scenario of autograft fixation under low mechanical load, we presented the first in vivo model: a rat fibula glued to the tibia, on which the TTCP/OPS-nPDA adhesive (n = 7) was shown to be effective in stabilizing the graft without displacement (a clinical success rate of 86% and 71% at 5 and 12 weeks, respectively) compared to a sham control (0%). Significant coverage of newly formed bone was particularly observed on the surface of the adhesive, thanks to the osteoinductive property of nPDA. To conclude, the TTCP/OPS-nPDA adhesive fulfilled many clinical requirements for the bone fixation, and potentially could be functionalized via nPDA to offer more biological activities, e.g., anti-infection after antibiotic loading.Lire moins >

Langue :

Anglais

Audience :

Internationale

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Date de dépôt :

2023-05-08T14:28:25Z
2023-05-17T07:38:45Z