Title :

Anticoagulant and antimicrobial finishing of non-woven polypropylene textiles

Author(s) :

Degoutin, Stephanie [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Jimenez, Maude [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Casetta, Mathilde [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Unité Matériaux et Transformations - UMR 8207 [UMET]
Bellayer, Séverine [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Chai, Feng [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Neut, Christel [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Kacem, I. [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Traisnel, Michel [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

Biomedical Materials

Volume number :

7

Pages :

35001

Publication date :

2012-02

ISSN :

1748-6041

HAL domain(s) :

Sciences de l'ingénieur [physics]/Matériaux

English abstract : [en]

Biomedical Materials Paper Anticoagulant and antimicrobial finishing of non-woven polypropylene textiles S Degoutin1,2, M Jimenez1,2, M Casetta1,2, S Bellayer1,3, F Chai1,4, N Blanchemain1,4, C Neut1,5, I Kacem1,2, M ...
Show more >Biomedical Materials Paper Anticoagulant and antimicrobial finishing of non-woven polypropylene textiles S Degoutin1,2, M Jimenez1,2, M Casetta1,2, S Bellayer1,3, F Chai1,4, N Blanchemain1,4, C Neut1,5, I Kacem1,2, M Traisnel1,2 and B Martel1,2 Published 23 February 2012 • © 2012 IOP Publishing Ltd Biomedical Materials, Volume 7, Number 3 Citation S Degoutin et al 2012 Biomed. Mater. 7 035001 1281 Total downloads 28 28 total citations on Dimensions. Turn on MathJax Get permission to re-use this article Share this article Share this content via email Share on Facebook (opens new window) Share on Twitter (opens new window) Share on Mendeley (opens new window) Article information Abstract The aim of this work is to prepare non-woven polypropylene (PP) textile functionalized with bioactive molecules in order to improve its anticoagulation and antibacterial properties. This paper describes the optimization of the grafting process of acrylic acid (AA) on low-pressure cold-plasma pre-activated PP, the characterization of the modified substrates and the effect of these modifications on the in vitro biological response towards cells. Then, the immobilization of gentamicin (aminoglycoside antibiotic) and heparin (anticoagulation agent) has been carried out on the grafted samples by either ionic interactions or covalent linkages. Their bioactivity has been investigated and related to the nature of their interactions with the substrate. For gentamicin-immobilized AA-grafted samples, an inhibition radius and a reduction of 99% of the adhesion of Escherichia coli have been observed when gentamicin was linked by ionic interactions, allowing the release of the antibiotic. By contrast, for heparin-immobilized AA-grafted PP samples, a strong increase of the anticoagulant effect up to 35 min has been highlighted when heparin was covalently bonded on the substrate, by contact with the blood drop.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
ENSCL
Inserm
CHU Lille
CNRS
INRA

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2019-05-16T15:15:26Z
2021-09-29T10:10:44Z