Long-term physicochemical stability of ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Long-term physicochemical stability of 5-fluorouracil at selected standardised rounded doses in polyolefin bags.
Auteur(s) :
Closset, M. [Auteur]
CHU UCL Namur
Onorati, S. [Auteur]
CHU UCL Namur
Colsoul, M. L. [Auteur]
CHU UCL Namur
Goderniaux, N. [Auteur]
CHU UCL Namur
Bihin, B. [Auteur]
CHU UCL Namur
Jamart, J. [Auteur]
CHU UCL Namur
Soumoy, L. [Auteur]
CHU UCL Namur
Hecq, J. D. [Auteur]
CHU UCL Namur
Odou, Pascal [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Galanti, L. [Auteur]
CHU UCL Namur
CHU UCL Namur
Onorati, S. [Auteur]
CHU UCL Namur
Colsoul, M. L. [Auteur]
CHU UCL Namur
Goderniaux, N. [Auteur]
CHU UCL Namur
Bihin, B. [Auteur]
CHU UCL Namur
Jamart, J. [Auteur]
CHU UCL Namur
Soumoy, L. [Auteur]
CHU UCL Namur
Hecq, J. D. [Auteur]
CHU UCL Namur
Odou, Pascal [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Galanti, L. [Auteur]
CHU UCL Namur
Titre de la revue :
Journal of Oncology Pharmacy Practice
Nom court de la revue :
J Oncol Pharm Pract
Pagination :
10781552231152618
Éditeur :
SAGE Publications
Date de publication :
2023-02-28
ISSN :
1477-092X
Mot(s)-clé(s) :
Stability
dose banding
5-fluorouracil
chromatography
dose banding
5-fluorouracil
chromatography
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Background
Chemotherapy doses are usually prescribed on the basis of body surface area but dose banding is emerging as an efficient alternative. Dose banding presents the possibility of in-advance preparation in a Centralized ...
Lire la suite >Background Chemotherapy doses are usually prescribed on the basis of body surface area but dose banding is emerging as an efficient alternative. Dose banding presents the possibility of in-advance preparation in a Centralized Intravenous Admixture Service. Aim of the study To evaluate the long-term stability of 5-fluorouracil at banded doses (700 mg and 800 mg) in polyolefin bags. Materials and methods Ten polyolefin bags were prepared under aseptic conditions and stored at 23 ± 2°C for 24 days. Five of them were composed of 14 mL 5-fluorocuracil (700 g) in 100 mL 0.9% sodium chloride solution and the five other of 16 mL 5-fluorouracil (800 mg) in 100 mL 0.9% sodium chloride solution. At defined times, physical stability parameters were assessed: optical densities, pH measurements, visual and microscopical inspections. Solutions concentrations were measured using high-performance liquid chromatography coupled with a photodiode array detector. Results No change was observed on pH and optical density measurements during the study period. Visual and microscopical inspections remained free of colour change, precipitate, microagregate or crystal. The concentrations of 5-Fluorouracil in 800 mg bags remained stable for 24 days while the concentration in 700 mg bags showed a stability of at least 17 days. Conclusion Five-fluorouracil at banded doses of 700 and 800 mg in polyolefin bags is physicochemically stable for at least 17 days at 23 ± 2°C. These results support the possibility of in advance centralised preparation.Lire moins >
Lire la suite >Background Chemotherapy doses are usually prescribed on the basis of body surface area but dose banding is emerging as an efficient alternative. Dose banding presents the possibility of in-advance preparation in a Centralized Intravenous Admixture Service. Aim of the study To evaluate the long-term stability of 5-fluorouracil at banded doses (700 mg and 800 mg) in polyolefin bags. Materials and methods Ten polyolefin bags were prepared under aseptic conditions and stored at 23 ± 2°C for 24 days. Five of them were composed of 14 mL 5-fluorocuracil (700 g) in 100 mL 0.9% sodium chloride solution and the five other of 16 mL 5-fluorouracil (800 mg) in 100 mL 0.9% sodium chloride solution. At defined times, physical stability parameters were assessed: optical densities, pH measurements, visual and microscopical inspections. Solutions concentrations were measured using high-performance liquid chromatography coupled with a photodiode array detector. Results No change was observed on pH and optical density measurements during the study period. Visual and microscopical inspections remained free of colour change, precipitate, microagregate or crystal. The concentrations of 5-Fluorouracil in 800 mg bags remained stable for 24 days while the concentration in 700 mg bags showed a stability of at least 17 days. Conclusion Five-fluorouracil at banded doses of 700 and 800 mg in polyolefin bags is physicochemically stable for at least 17 days at 23 ± 2°C. These results support the possibility of in advance centralised preparation.Lire moins >
Langue :
Anglais
Audience :
Internationale
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Date de dépôt :
2023-05-25T02:17:45Z
2023-06-28T11:14:55Z
2023-06-28T11:14:55Z