Association between Urinary Metabolites ...
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Article dans une revue scientifique: Article original
DOI :
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Title :
Association between Urinary Metabolites and the Exposure of Intensive Care Newborns to Plasticizers of Medical Devices Used for Their Care Management.
Author(s) :
Bernard, Lise [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Bouattour, Yassine [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Masse, Morgane [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Boeuf, Benoît [Auteur]
Service Urgences Pédiatriques et UHCD [CHU Clermont-Ferrand]
Décaudin, Bertrand [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
GENAY, Stéphanie [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Lambert, Céline [Auteur]
Moreau, Emmanuelle [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Pereira, Bruno [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Pinguet, Jérémy [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Richard, Damien [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Sautou, Valérie [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
For The Armed Study, G. R. O. U. P. [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Bouattour, Yassine [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Masse, Morgane [Auteur]

Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Boeuf, Benoît [Auteur]
Service Urgences Pédiatriques et UHCD [CHU Clermont-Ferrand]
Décaudin, Bertrand [Auteur]

Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
GENAY, Stéphanie [Auteur]

Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Lambert, Céline [Auteur]
Moreau, Emmanuelle [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Pereira, Bruno [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Pinguet, Jérémy [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Richard, Damien [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
Sautou, Valérie [Auteur]
Université d'Auvergne - Clermont-Ferrand I [UdA]
For The Armed Study, G. R. O. U. P. [Auteur]
Journal title :
Metabolites
Volume number :
11
Pages :
252
Publisher :
MDPI
Publication date :
2021-05-05
ISSN :
2218-1989
Keyword(s) :
medical devices
PVC
plasticizers
exposure
neonatal intensive care unit
urinary metabolites
PVC
plasticizers
exposure
neonatal intensive care unit
urinary metabolites
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Care management of newborns in the neonatal intensive care unit (NICU) requires numerous PVC (PolyVinyl Chloride) medical devices (MD) containing plasticizers that can migrate and contaminate the patient. We measured the ...
Show more >Care management of newborns in the neonatal intensive care unit (NICU) requires numerous PVC (PolyVinyl Chloride) medical devices (MD) containing plasticizers that can migrate and contaminate the patient. We measured the magnitude of neonates’ exposure to plasticizers (di-ethylhexylphthalate (DEHP) and alternatives) in relation to urinary concentrations of their metabolites. Plasticizers’ exposure was evaluated (1) by calculating the amounts of plasticizers prone to be released from each MD used for care management, and (2) by measuring the patients’ urinary levels of each plasticizers’ metabolites. 104 neonates were enrolled. They were exposed to di-isononylphthalate (DINP), especially via transfusion and infusion MD, and to DEHP via ECMO (Extra Corporeal Membrane Oxygenation) and respiratory assistance MD. Mean exposure doses exceeded the derived no-effect level of DINP and DEHP by a 10-fold and a 1000-fold factor. No PVC MD were plasticized with di-isononylcyclohexane-1,2-dicarboxylate (DINCH). High urinary concentrations of DEHP metabolites were directly correlated with DEHP exposure through ECMO MD. Urinary concentrations of DINP metabolites in transfused patients were also high. DINCH metabolites were found in urine, suggesting another route of exposure. Neonates in NICU are considerably exposed to plasticizers, with magnitudes varying with the type of MD used. The high exposure to DEHP and DINP leads to a risk of their metabolites’ toxicity.Show less >
Show more >Care management of newborns in the neonatal intensive care unit (NICU) requires numerous PVC (PolyVinyl Chloride) medical devices (MD) containing plasticizers that can migrate and contaminate the patient. We measured the magnitude of neonates’ exposure to plasticizers (di-ethylhexylphthalate (DEHP) and alternatives) in relation to urinary concentrations of their metabolites. Plasticizers’ exposure was evaluated (1) by calculating the amounts of plasticizers prone to be released from each MD used for care management, and (2) by measuring the patients’ urinary levels of each plasticizers’ metabolites. 104 neonates were enrolled. They were exposed to di-isononylphthalate (DINP), especially via transfusion and infusion MD, and to DEHP via ECMO (Extra Corporeal Membrane Oxygenation) and respiratory assistance MD. Mean exposure doses exceeded the derived no-effect level of DINP and DEHP by a 10-fold and a 1000-fold factor. No PVC MD were plasticized with di-isononylcyclohexane-1,2-dicarboxylate (DINCH). High urinary concentrations of DEHP metabolites were directly correlated with DEHP exposure through ECMO MD. Urinary concentrations of DINP metabolites in transfused patients were also high. DINCH metabolites were found in urine, suggesting another route of exposure. Neonates in NICU are considerably exposed to plasticizers, with magnitudes varying with the type of MD used. The high exposure to DEHP and DINP leads to a risk of their metabolites’ toxicity.Show less >
Language :
Anglais
Audience :
Internationale
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Submission date :
2023-05-25T03:08:39Z
2023-08-30T09:14:47Z
2023-08-30T09:14:47Z
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