Long-term physico-chemical stability of ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Long-term physico-chemical stability of 5-fluorouracile at standardised rounded doses (SRD) in MyFuser® portable infusion pump.
Auteur(s) :
Closset, Mélanie [Auteur]
CHU UCL Namur
Onorati, Sabrina [Auteur]
CHU UCL Namur
Colsoul, Marie-Lise [Auteur]
CHU UCL Namur
Goderniaux, Nicolas [Auteur]
CHU UCL Namur
Bihin, Benoît [Auteur]
CHU UCL Namur
Jamart, Jacques [Auteur]
CHU UCL Namur
Soumoy, Laura [Auteur]
CHU UCL Namur
Hecq, Jean-Daniel [Auteur]
CHU UCL Namur
Odou, Pascal [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Galanti, Laurence [Auteur]
CHU UCL Namur
CHU UCL Namur
Onorati, Sabrina [Auteur]
CHU UCL Namur
Colsoul, Marie-Lise [Auteur]
CHU UCL Namur
Goderniaux, Nicolas [Auteur]
CHU UCL Namur
Bihin, Benoît [Auteur]
CHU UCL Namur
Jamart, Jacques [Auteur]
CHU UCL Namur
Soumoy, Laura [Auteur]
CHU UCL Namur
Hecq, Jean-Daniel [Auteur]
CHU UCL Namur
Odou, Pascal [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Galanti, Laurence [Auteur]
CHU UCL Namur
Titre de la revue :
Journal of Chemotherapy
Nom court de la revue :
J Chemother
Numéro :
33
Pagination :
1-5
Éditeur :
Taylor & Francis Online
Date de publication :
2021-04-17
ISSN :
1973-9478
Mot(s)-clé(s) :
Dose-Banding
5-FU
Chromatography
stability study
portable infusion pump
CIVAS
5-FU
Chromatography
stability study
portable infusion pump
CIVAS
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Management of chemotherapies is a strategic issue for european healthcare. Dose-banding enables to reduce waiting time of patients in day care units and drug wastage. The aim of this study was to assess the stability of ...
Lire la suite >Management of chemotherapies is a strategic issue for european healthcare. Dose-banding enables to reduce waiting time of patients in day care units and drug wastage. The aim of this study was to assess the stability of 5-Fluorouracile (5-FU) at standardised rounded doses of 4 and 5 g in MyFuser® portable infusion pump for in-advance preparation. Ten MyFuser® (4 and 5 gr 5-FU added to NaCl 0.9%) were prepared under aseptic conditions and stored at room temperature (23 ± 2 °C) for 28 days then at 30 °C for three days. Physical stability tests were periodically performed: visual and microscopic inspection, pH measurements and optical densities. The concentration of solutions was measured by High Performance Liquid Chromatography/UV detector. Results confirm the stability of 5-FU at selected SRD of 4 g and 5 g with NaCl 0.9% in MyFuser® for at least 28 days at room temperature and three days at 30 °C, allowing in-advance preparation.Lire moins >
Lire la suite >Management of chemotherapies is a strategic issue for european healthcare. Dose-banding enables to reduce waiting time of patients in day care units and drug wastage. The aim of this study was to assess the stability of 5-Fluorouracile (5-FU) at standardised rounded doses of 4 and 5 g in MyFuser® portable infusion pump for in-advance preparation. Ten MyFuser® (4 and 5 gr 5-FU added to NaCl 0.9%) were prepared under aseptic conditions and stored at room temperature (23 ± 2 °C) for 28 days then at 30 °C for three days. Physical stability tests were periodically performed: visual and microscopic inspection, pH measurements and optical densities. The concentration of solutions was measured by High Performance Liquid Chromatography/UV detector. Results confirm the stability of 5-FU at selected SRD of 4 g and 5 g with NaCl 0.9% in MyFuser® for at least 28 days at room temperature and three days at 30 °C, allowing in-advance preparation.Lire moins >
Langue :
Anglais
Audience :
Internationale
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Date de dépôt :
2023-05-25T03:10:09Z
2023-09-27T07:22:39Z
2023-09-27T07:22:39Z