Title :

Outcomes of older patients with follicular lymphoma using individual data from 5922 patients in 18 randomized controlled trials.

Author(s) :

Casulo, Carla [Auteur]
University of Rochester Medical Center [URMC]
Dixon, Jesse G. [Auteur]
Mayo Clinic [Rochester]
Ou, Fang-Shu [Auteur]
Mayo Clinic [Rochester]
Hoster, Eva [Auteur]
University-Hospital Munich-Großhadern [München]
Peterson, Bruce A. [Auteur]
Hochster, Howard S. [Auteur]
Rutgers cancer institute of New Jersey [Newark, NJ]
Brice, Pauline [Auteur]
Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Ladetto, Marco [Auteur]
Hiddemann, Wolfgang [Auteur]
Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München [LMU]
Marcus, Robert [Auteur]
King's College Hospital [KCH]
Kimby, Eva [Auteur]
Karolinska Institutet [Stockholm]
Herold, Michael [Auteur]
Helios Klinikum [Erfurt]
Nielsen, Tina [Auteur]
F. Hoffmann-La Roche [Basel]
Morschhauser, Franck [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Rummel, Mathias [Auteur]
Justus-Liebig-Universität Gießen = Justus Liebig University [JLU]
Hagenbeek, Anton [Auteur]
Amsterdam University Medical Centers [Amsterdam UMC]
Vitolo, Umberto [Auteur]
Istituto di Ricovero e Cura a Carattere Scientifico [IRCCS]
Salles, Gilles A. [Auteur]
Memorial Sloan Kettering Cancer Center [MSKCC]
Shi, Qian [Auteur]
Mayo Clinic [Rochester]
Flowers, Christopher R. [Auteur]
The University of Texas M.D. Anderson Cancer Center [Houston]

Journal title :

Blood Advances

Abbreviated title :

Blood Adv

Volume number :

5

Pages :

1737-1745

Publication date :

2021-03-23

ISSN :

2473-9537

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Limited data exist to describe the clinical features and outcomes for elderly patients with follicular lymphoma (FL). The Follicular Lymphoma Analysis of Surrogacy Hypothesis (FLASH) group performed a prospectively planned ...
Show more >Limited data exist to describe the clinical features and outcomes for elderly patients with follicular lymphoma (FL). The Follicular Lymphoma Analysis of Surrogacy Hypothesis (FLASH) group performed a prospectively planned pooled analysis of individual patient data from first-line randomized controlled trials (RCTs) and examined associations between age (≤70 vs >70 years), clinical characteristics, and FL outcomes. We identified 18 multicenter clinical RCTs in the FLASH database that enrolled elderly patients (>70 years). Primary end points were early disease outcomes, CR24 and CR30, and progression-free survival (PFS) at 24 months (PFS24). Secondary end points were PFS and overall survival (OS). We identified 5922 previously untreated FL patients from 18 RCTs. Patients age >70 years (vs ≤70 years) more commonly had elevated lactate dehydrogenase, hemoglobin <12 g/dL, ECOG PS ≥2, and elevated β2-microglobulin. Median follow-up was 5.6 years. Patients >70 years did not differ from patients ≤70 years in rates of CR24, CR30, or PFS24. With a median OS of 14.6 years for all patients, median OS was 7.4 and 15.7 years for patients >70 and ≤70 years of age, respectively (hazard ratio = 2.35; 95% confidence interval = 2.03-2.73; P < .001). Age >70 years was a significant predictor of OS and PFS due to higher rates of death without progression, but not PFS24, CR24, or CR30. FL patients >70 years treated on trials have similar early disease outcomes to younger patients. There is no disease-specific outcome difference between age groups. Age alone should not disqualify patients from standard treatments or RCTs.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365

Submission date :

2023-05-25T03:12:12Z
2024-07-02T09:09:00Z