Controversies in the Treatment of Peripheral ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
PMID :
Permalink :
Title :
Controversies in the Treatment of Peripheral T-cell Lymphoma
Author(s) :
Bachy, Emmanuel [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Broccoli, Alessandro [Auteur]
Dearden, Claire [Auteur]
Royal Marsden NHS Foundation Trust
De Leval, Laurence [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Gaulard, Philippe [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Koch, Raphael [Auteur]
University Medical Center Göttingen [UMG]
Morschhauser, Franck [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Trümper, Lorenz [Auteur]
University Medical Center Göttingen [UMG]
Zinzani, Pier Luigi [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Broccoli, Alessandro [Auteur]
Dearden, Claire [Auteur]
Royal Marsden NHS Foundation Trust
De Leval, Laurence [Auteur]
Université de Lausanne = University of Lausanne [UNIL]
Gaulard, Philippe [Auteur]
Institut Mondor de Recherche Biomédicale [IMRB]
Koch, Raphael [Auteur]
University Medical Center Göttingen [UMG]
Morschhauser, Franck [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Trümper, Lorenz [Auteur]
University Medical Center Göttingen [UMG]
Zinzani, Pier Luigi [Auteur]
Journal title :
HemaSphere
Volume number :
4
Pages :
e461
Publisher :
Lippincott, Williams & Wilkins
Publication date :
2020-10-20
ISSN :
2572-9241
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Peripheral T-cell lymphomas are a heterogeneous group of rare diseases with an aggressive behavior and dismal prognosis. Their classification is complex and still evolving, and several biomolecular markers now help refine ...
Show more >Peripheral T-cell lymphomas are a heterogeneous group of rare diseases with an aggressive behavior and dismal prognosis. Their classification is complex and still evolving, and several biomolecular markers now help refine the prognosis of specific disease entities, although still have limited impact in tailoring the treatment. First-line treatment strategies can cure only a minority of patients and relapsed-refractory disease still represents the major cause of failure. Frontline autologous transplantation may have an impact in the consolidation of response; however, its role is still questioned as far as complete responses obtained after induction chemotherapy are concerned. Newer drugs are now being evaluated in clinical trials, but effective salvage strategies for those who experience treatment failures are lacking. Here we review and discuss the most controversial aspects of diagnosis and treatment of peripheral T-cell lymphomas.Show less >
Show more >Peripheral T-cell lymphomas are a heterogeneous group of rare diseases with an aggressive behavior and dismal prognosis. Their classification is complex and still evolving, and several biomolecular markers now help refine the prognosis of specific disease entities, although still have limited impact in tailoring the treatment. First-line treatment strategies can cure only a minority of patients and relapsed-refractory disease still represents the major cause of failure. Frontline autologous transplantation may have an impact in the consolidation of response; however, its role is still questioned as far as complete responses obtained after induction chemotherapy are concerned. Newer drugs are now being evaluated in clinical trials, but effective salvage strategies for those who experience treatment failures are lacking. Here we review and discuss the most controversial aspects of diagnosis and treatment of peripheral T-cell lymphomas.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Research team(s) :
Modélisation biopharmaceutique et pharmacocinétique
Submission date :
2023-05-25T03:26:08Z
2023-09-22T14:49:47Z
2023-09-22T14:49:47Z
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