Outcome and Characteristics of Invasive ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Outcome and Characteristics of Invasive Fungal Infections in critically ill burn patients: A multicenter retrospective study.
Auteur(s) :
Maurel, V. [Auteur]
SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé [SYMMES]
Denis, B. [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Camby, M. [Auteur]
Jeanne, Mathieu [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Cornesse, A. [Auteur]
Glavnik, B. [Auteur]
Alanio, A. [Auteur]
Rousseau, A. F. [Auteur]
Lefloch, R. [Auteur]
Lagrange-Xelot, M. [Auteur]
Textoris, J. [Auteur]
Wiramus, S. [Auteur]
De Tymowski, C. [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Legrand, M. [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé [SYMMES]
Denis, B. [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Camby, M. [Auteur]
Jeanne, Mathieu [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Cornesse, A. [Auteur]
Glavnik, B. [Auteur]
Alanio, A. [Auteur]
Rousseau, A. F. [Auteur]
Lefloch, R. [Auteur]
Lagrange-Xelot, M. [Auteur]
Textoris, J. [Auteur]
Wiramus, S. [Auteur]
De Tymowski, C. [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Legrand, M. [Auteur]
Assistance publique - Hôpitaux de Paris (AP-HP) [AP-HP]
Titre de la revue :
Mycoses
Nom court de la revue :
Mycoses
Numéro :
63
Pagination :
535-542
Éditeur :
Wiley
Date de publication :
2020-06
ISSN :
1439-0507
Mot(s)-clé(s) en anglais :
yeast infection
mortality
invasive fungal infection
filamentous infection
burn patients
mortality
invasive fungal infection
filamentous infection
burn patients
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Background: Characteristics and outcome of invasive fungal infection (IFI) in critically ill burn patients have been poorly explored.
Objectives: We report the factors associated with 90-day mortality in a multicentre ...
Lire la suite >Background: Characteristics and outcome of invasive fungal infection (IFI) in critically ill burn patients have been poorly explored. Objectives: We report the factors associated with 90-day mortality in a multicentre retrospective European study. Patients/methods: All burn patients with confirmed IFI admitted between 1 January 2010 to 31 December 2015 in 10 centres in France and Belgium were included. Results: Ninety-four patients were enrolled with 110 cases of IFIs: 79 (71.8%) were yeasts IFI and 31 (28.2%) filamentous IFI. Incidence was 1% among admitted patients. The 90-day mortality was 37.2% for all IFIs combined, 52% for filamentous infection and 31.9% for yeast infection. Patients with more than one IFI had a higher 90-day mortality than patients with only one episode (61.5% vs 33.5% (P = .006)). In multivariate analysis, higher Simplified Acute Physiology Score II (OR = 1.05 (95% CI: 1.02-1.09) P = .003), bacterial co-infection (OR = 3.85 (95% CI: 1.23-12.01), P = .014) and use of skin allografts at the time of IFI diagnosis (OR = 3.87 (95% CI: 1.31-11.42), P = .021) were associated with 90-day mortality. Conclusions: Although rare, invasive fungal infections remain associated with poor outcome in burn patients. Bacterial co-infection and presence of allograft were potentially modifiable factors independently associated with outcome.Lire moins >
Lire la suite >Background: Characteristics and outcome of invasive fungal infection (IFI) in critically ill burn patients have been poorly explored. Objectives: We report the factors associated with 90-day mortality in a multicentre retrospective European study. Patients/methods: All burn patients with confirmed IFI admitted between 1 January 2010 to 31 December 2015 in 10 centres in France and Belgium were included. Results: Ninety-four patients were enrolled with 110 cases of IFIs: 79 (71.8%) were yeasts IFI and 31 (28.2%) filamentous IFI. Incidence was 1% among admitted patients. The 90-day mortality was 37.2% for all IFIs combined, 52% for filamentous infection and 31.9% for yeast infection. Patients with more than one IFI had a higher 90-day mortality than patients with only one episode (61.5% vs 33.5% (P = .006)). In multivariate analysis, higher Simplified Acute Physiology Score II (OR = 1.05 (95% CI: 1.02-1.09) P = .003), bacterial co-infection (OR = 3.85 (95% CI: 1.23-12.01), P = .014) and use of skin allografts at the time of IFI diagnosis (OR = 3.87 (95% CI: 1.31-11.42), P = .021) were associated with 90-day mortality. Conclusions: Although rare, invasive fungal infections remain associated with poor outcome in burn patients. Bacterial co-infection and presence of allograft were potentially modifiable factors independently associated with outcome.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Date de dépôt :
2023-05-25T03:40:09Z
2024-05-22T10:00:47Z
2024-05-22T10:00:47Z