Dynamic particle count during drug infusion: ...
Type de document :
Article dans une revue scientifique: Article original
URL permanente :
Titre :
Dynamic particle count during drug infusion: Method characterization and analysis of factors influencing results
Auteur(s) :
Martin Mena, Anthony [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - EA 7365
Masse, Morgane [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Negrier, Laura [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Carta, Natacha [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Pettinari, Alice [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Barthelemy, Christine [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Odou, Pascal [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
GENAY, Stéphanie [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Décaudin, Bertrand [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - EA 7365
Masse, Morgane [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Negrier, Laura [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Carta, Natacha [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Pettinari, Alice [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Barthelemy, Christine [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Odou, Pascal [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
GENAY, Stéphanie [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Décaudin, Bertrand [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Titre de la revue :
Journal of Drug Delivery Science and Technology
Nom court de la revue :
J. Drug Deliv. Sci. Technol.
Numéro :
55
Pagination :
101473
Éditeur :
Elsevier
Date de publication :
2020-03-28
ISSN :
1773-2247
Mot(s)-clé(s) :
Drug incompatibility
Subvisible particles
Particle size
Dynamic particle count
Drug infusion systems
Particulate matter
Subvisible particles
Particle size
Dynamic particle count
Drug infusion systems
Particulate matter
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Introduction
Drug incompatibilities are a constant problem in hospital care units. The multiplication of drugs injected simultaneously during patient therapy increases the risk of incompatibilities and can have a ...
Lire la suite >Introduction Drug incompatibilities are a constant problem in hospital care units. The multiplication of drugs injected simultaneously during patient therapy increases the risk of incompatibilities and can have a significant clinical impact. The purpose of this research was to characterize and analyze various parameters inducing variability in particle counting using a dynamic particle counter. Materials and methods Observations were performed on two-ports manifolds with two incompatible drugs, thus creating a quantifiable particulate charge. We analyzed the number of different-sized particles measured during the experiment as well as their cumulative distribution. The parameters studied on particle count were: position of the infusion device, environmental vibrations and total flow rate. Results Significantly higher particle counts were observed when the infusion device was in a vertical position or disturbed by vibrations. Total flow rate significantly reduced the number of particles. Conclusion This study enabled us to identify several variation factors through dynamic particle counting. These factors should be taken into account to reduce variability in results.Lire moins >
Lire la suite >Introduction Drug incompatibilities are a constant problem in hospital care units. The multiplication of drugs injected simultaneously during patient therapy increases the risk of incompatibilities and can have a significant clinical impact. The purpose of this research was to characterize and analyze various parameters inducing variability in particle counting using a dynamic particle counter. Materials and methods Observations were performed on two-ports manifolds with two incompatible drugs, thus creating a quantifiable particulate charge. We analyzed the number of different-sized particles measured during the experiment as well as their cumulative distribution. The parameters studied on particle count were: position of the infusion device, environmental vibrations and total flow rate. Results Significantly higher particle counts were observed when the infusion device was in a vertical position or disturbed by vibrations. Total flow rate significantly reduced the number of particles. Conclusion This study enabled us to identify several variation factors through dynamic particle counting. These factors should be taken into account to reduce variability in results.Lire moins >
Langue :
Anglais
Audience :
Internationale
Établissement(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Date de dépôt :
2023-05-25T03:56:30Z
2023-09-13T07:09:38Z
2023-09-13T07:09:38Z