Titre :

GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation.

Auteur(s) :

Pellegrino, G. [Auteur]
Martin, M. [Auteur]
Allet, C. [Auteur]
Lhomme, T. [Auteur]
Geller, S. [Auteur]
Franssen, D. [Auteur]
Mansuy, V. [Auteur]
Manfredi-Lozano, M. [Auteur]
Coutteau-Robles, A. [Auteur]
Delli, V. [Auteur]
Rasika, S. [Auteur]
Mazur, D. [Auteur]
Loyens, A. [Auteur]
Tena-Sempere, M. [Auteur]
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Pralong, F. P. [Auteur]
Ciofi, P. [Auteur]
Corfas, G. [Auteur]
Parent, A. S. [Auteur]
Ojeda, S. R. [Auteur]
Sharif, Ariane [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Prevot, Vincent [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Titre de la revue :

Nature Neuroscience

Date de publication :

2021-11-20

ISSN :

1546-1726

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Neurons that produce gonadotropin-releasing hormone (GnRH), which control fertility, complete their nose-to-brain migration by birth. However, their function depends on integration within a complex neuroglial network during ...
Lire la suite >Neurons that produce gonadotropin-releasing hormone (GnRH), which control fertility, complete their nose-to-brain migration by birth. However, their function depends on integration within a complex neuroglial network during postnatal development. Here, we show that rodent GnRH neurons use a prostaglandin D2 receptor DP1 signaling mechanism during infancy to recruit newborn astrocytes that 'escort' them into adulthood, and that the impairment of postnatal hypothalamic gliogenesis markedly alters sexual maturation by preventing this recruitment, a process mimicked by the endocrine disruptor bisphenol A. Inhibition of DP1 signaling in the infantile preoptic region, where GnRH cell bodies reside, disrupts the correct wiring and firing of GnRH neurons, alters minipuberty or the first activation of the hypothalamic-pituitary-gonadal axis during infancy, and delays the timely acquisition of reproductive capacity. These findings uncover a previously unknown neuron-to-neural-progenitor communication pathway and demonstrate that postnatal astrogenesis is a basic component of a complex set of mechanisms used by the neuroendocrine brain to control sexual maturation.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Date de dépôt :

2023-05-30T06:58:54Z
2023-08-30T07:56:14Z