Titre :

Chemical, biological and microbiological evaluation of cyclodextrin finished polyamide inguinal meshes

Auteur(s) :

El Ghoul, Y. [Auteur]
Laboratoire de Chimie Organique et Macromoleculaire [UMR CNRS 8009]
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Laurent, T. [Auteur]
Laboratoire de Chimie Organique et Macromoleculaire [UMR CNRS 8009]
Campagne, Christine [Auteur]
Génie et Matériaux Textiles [GEMTEX]
El Achari, Ahmida [Auteur]
Génie et Matériaux Textiles [GEMTEX]
Roudesli, S. [Auteur]
Laboratoire Polymères, Biopolymères, Matériaux Organiques [Monastir] [LPBMO]
Morcellet, Michel [Auteur]
Laboratoire de Chimie Organique et Macromoleculaire [UMR CNRS 8009]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Chai, Feng [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008

Titre de la revue :

Acta Biomaterialia

Nom court de la revue :

Acta Biomater.

Numéro :

4

Pagination :

1392-1400

Date de publication :

2015-07-20

ISSN :

1742-7061

Mot(s)-clé(s) :

cyclodextrin
citric acid
antibiotic release
polyamide
textile

Discipline(s) HAL :

Chimie/Matériaux

Résumé en anglais : [en]

This study describes the use of cyclodextrins (CDs) as a finishing agent of polyamide (PA) fibers used in order to obtain inguinal meshes with improved antibiotic delivery properties. The finishing process involved ...
Lire la suite >This study describes the use of cyclodextrins (CDs) as a finishing agent of polyamide (PA) fibers used in order to obtain inguinal meshes with improved antibiotic delivery properties. The finishing process involved polymerization between citric acid and CDs, which yielded a cross-linked polymer that physically adhered to the surface of PA fibers. This permanent functionalization was characterized by evaluating the damping property with a polar liquid (glycerol) via the drop contact angle method for various rates of modification of the fabrics. The biological and microbiological effects of the PA, which were functionalized with hydroxypropylated derivate of γ-CD (HP-γ-CDs) and charged with ciprofloxacin (CFX), were evaluated by cell culture assays. We observed a good adhesion and proliferation of fibroblastic cells (NIH3T3) after 3 and 6 days and no detectable toxicity of the modified substrate. The in vitro antibacterial activity of the HP-γ-CD grafted PA fabrics charged with CFX against the bacteria Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli was greatly superior to that of the virgin sample within a 24 h batch experiment in human blood plasma medium. In conclusion, these results from our study offer an insight into the efficient performance of CDs as drug delivery systems for multiple applications in the fields of biomaterials and medical textiles.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
ENSAIT
Junia HEI

Collections :

• Génie des matériaux textiles (GEMTEX) - ULR 2641
• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Ingénierie des Systèmes Polymères

Date de dépôt :

2023-06-20T01:50:01Z
2023-10-11T09:31:52Z