Title :

Chemical, biological and microbiological evaluation of cyclodextrin finished polyamide inguinal meshes

Author(s) :

El Ghoul, Y. [Auteur]
Laboratoire de Chimie Organique et Macromoleculaire [UMR CNRS 8009]
Blanchemain, Nicolas [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Laurent, T. [Auteur]
Laboratoire de Chimie Organique et Macromoleculaire [UMR CNRS 8009]
Campagne, Christine [Auteur]
Génie et Matériaux Textiles [GEMTEX]
El Achari, Ahmida [Auteur]
Génie et Matériaux Textiles [GEMTEX]
Roudesli, S. [Auteur]
Laboratoire Polymères, Biopolymères, Matériaux Organiques [Monastir] [LPBMO]
Morcellet, Michel [Auteur]
Laboratoire de Chimie Organique et Macromoleculaire [UMR CNRS 8009]
Martel, Bernard [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Chai, Feng [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008

Journal title :

Acta Biomaterialia

Abbreviated title :

Acta Biomater.

Volume number :

4

Pages :

1392-1400

Publication date :

2015-07-20

ISSN :

1742-7061

Keyword(s) :

cyclodextrin
citric acid
antibiotic release
polyamide
textile

HAL domain(s) :

Chimie/Matériaux

English abstract : [en]

This study describes the use of cyclodextrins (CDs) as a finishing agent of polyamide (PA) fibers used in order to obtain inguinal meshes with improved antibiotic delivery properties. The finishing process involved ...
Show more >This study describes the use of cyclodextrins (CDs) as a finishing agent of polyamide (PA) fibers used in order to obtain inguinal meshes with improved antibiotic delivery properties. The finishing process involved polymerization between citric acid and CDs, which yielded a cross-linked polymer that physically adhered to the surface of PA fibers. This permanent functionalization was characterized by evaluating the damping property with a polar liquid (glycerol) via the drop contact angle method for various rates of modification of the fabrics. The biological and microbiological effects of the PA, which were functionalized with hydroxypropylated derivate of γ-CD (HP-γ-CDs) and charged with ciprofloxacin (CFX), were evaluated by cell culture assays. We observed a good adhesion and proliferation of fibroblastic cells (NIH3T3) after 3 and 6 days and no detectable toxicity of the modified substrate. The in vitro antibacterial activity of the HP-γ-CD grafted PA fabrics charged with CFX against the bacteria Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli was greatly superior to that of the virgin sample within a 24 h batch experiment in human blood plasma medium. In conclusion, these results from our study offer an insight into the efficient performance of CDs as drug delivery systems for multiple applications in the fields of biomaterials and medical textiles.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
ENSAIT
Junia HEI

Collections :

• Génie des matériaux textiles (GEMTEX) - ULR 2641
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Ingénierie des Systèmes Polymères

Submission date :

2023-06-20T01:50:01Z
2023-10-11T09:31:52Z