Titre :

Hematopoietic stem cell transplantation for acute lymphoblastic leukemia: why do adolescents and young adults outcomes differ from those of children? A retrospective study on behalf of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)

Auteur(s) :

Grain, Audrey [Auteur correspondant]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Rialland-Battisti, Fanny [Auteur]
Chevallier, Patrice [Auteur]
Blin, Nicolas [Auteur]
Dalle, Jean-Hugues [Auteur]
Hôpital Robert Debré
Michel, Gérard [Auteur]
Centre d'études et de recherche sur les services de santé et la qualité de vie [CEReSS]
Dhédin, Nathalie [Auteur]
Peffault de Latour, Regis [Auteur]
Pochon, Cécile [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bertrand, Yves [Auteur]
Hospices Civils de Lyon [HCL]
Sirvent, Anne [Auteur]
CHU Montpellier = Montpellier University Hospital
Jubert, Charlotte [Auteur]
Forcade, Edouard [Auteur]
Berceanu, Ana [Auteur]
Gandemer, Virginie [Auteur]
Institut de Génétique et Développement de Rennes [IGDR]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Schneider, Pascale [Auteur]
Bay, Jacques-Olivier [Auteur]
CHU Estaing [Clermont-Ferrand]
Rohrlich, Pierre-Simon [Auteur]
Brissot, Eolia [Auteur]
Paillard, Catherine [Auteur]
Plantaz, Dominique [Auteur]
Nguyen Quoc, Stéphanie [Auteur]
Gonzales, Fanny [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Maillard, Natacha [Auteur]
Planche, Lucie [Auteur]
Baruchel, André [Auteur]
Hôpital Robert Debré

Titre de la revue :

Journal of Cancer Research and Clinical Oncology

Pagination :

1473-1483

Éditeur :

Springer Verlag

Date de publication :

2023-04

ISSN :

0171-5216

Mot(s)-clé(s) en anglais :

Acute lymphoblastic leukemia
Adolescents and young adults
Graft versus host disease
Hematopoietic stem cell transplantation

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Hématologie

Résumé en anglais : [en]

Purpose: In the acute lymphoblastic leukemia (ALL) landscape, adolescents and young adults (AYA) often present high-risk diseases and increased chemotherapy-related toxicity. Studies analyzing the outcomes of AYA after ...
Lire la suite >Purpose: In the acute lymphoblastic leukemia (ALL) landscape, adolescents and young adults (AYA) often present high-risk diseases and increased chemotherapy-related toxicity. Studies analyzing the outcomes of AYA after hematopoietic stem cell transplantation (HSCT) are scarce. Our study aimed to compare the outcomes of children and AYA with ALL after HSCT and to determine the factors influencing potential differences.Method: 891 patients, from the SFGM-TC registry, aged between 1 and 25 years who received HSCT between 2005 and 2012 were included. The outcomes of AYA were compared to the ones of their younger counterparts.Results: Five-year OS and GRFS were lower in AYA: 53.1% versus 64% and 36% versus 47% (p = 0.0012 and p = 0.007, respectively). WhileCIR was similar in both groups, 5 year-treatment related mortality was higher in AYA: 19% versus 13% (p = 0.04). The lower GRFS in AYA was mainly explained by a higher chronic graft versus host disease (cGvHD) incidence: 32% versus 19% (p < 0.001). Use of peripheral blood stem cells and use of anti-thymoglobulin appeared to be the main factors impacting cGvHD occurrence in AYA.Conclusion: AYA have worse outcomes than children after HSCT for ALL because of a greater risk of TRM due to cGvHD. HSCT practices should be questioned in this population.Keywords: Acute lymphoblastic leukemia; Adolescents and young adults; Graft versus host disease; Hematopoietic stem cell transplantation.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL